Clinical correlates of serum total bilirubin levels in 1006 patients with sepsis: linear regression analysis
| Clinical variables | Univariate analysis | Stepwise multivariate analysis | ||
| Estimates (SE) | p Value | Estimates (SE) | p Value | |
| Age | −0.0023 (0.0008) | 0.004 | – | NS |
| Sex, female vs male | −0.1314 (0.0278) | <0.0001 | −0.0920 (0.0244) | <0.0001 |
| Septic shock | 0.0539 (0.0281) | 0.055 | – | NS |
| Diabetes | −0.1033 (0.0315) | 0.001 | −0.1118 (0.0275) | 0.0002 |
| Chronic liver disorder | 0.7569 (0.0538) | <0.0001 | 0.5780 (0.0543) | <0.0001 |
| Pneumonia | −0.1362 (0.0276) | <0.0001 | −0.1241 (0.0248) | <0.0001 |
| Aspiration | −0.0704 (0.0491) | 0.152 | – | NS |
| Multiple transfusions | 0.3756 (0.0741) | <0.0001 | – | NS |
| Trauma | −0.0512 (0.1460) | 0.700 | – | NS |
| History of alcohol abuse | 0.2591 (0.0405) | <0.0001 | – | NS |
| History of steroid use | −0.0824 (0.0465) | 0.077 | – | NS |
| PEEP >5 cm H2O | 0.0579 (0.0296) | 0.051 | – | NS |
| Organ dysfunction | NS | |||
| Respiratory | 0.1000 (0.0294) | 0.0007 | 0.0928 (0.0257) | <0.0001 |
| Cardiovascular | 0.0638 (0.0313) | 0.042 | – | NS |
| Renal | 0.1117 (0.0289) | 0.0001 | 0.0619 (0.0256) | 0.022 |
| Haematological | 0.4932 (0.0398) | <0.0001 | 0.3018 (0.0400) | <0.0001 |
NS, not significant; PEEP, positive end-expiratory pressure.