Associations of serum total bilirubin levels with sepsis-related ARDS risk and mortality: multivariate logistic regression analysis
| Serum bilirubin levels | ARDS development | ARDS 28-day mortality | ARDS 60-day mortality | |||
| OR* (95% CI) | p Value | OR† (95% CI) | p Value | OR† (95% CI) | p Value | |
| On ICU admission | ||||||
| Bilirubin | 1.07 (1.03 to 1.13) | 0.003 | 1.20 (1.07 to 1.35) | 0.002 | 1.18 (1.05 to 1.29) | 0.004 |
| Log-bilirubin | 2.17 (1.46 to 3.25) | 0.0001 | 2.86 (1.36 to 6.01) | 0.005 | 2.70 (1.30 to 5.61) | 0.008 |
| Bilirubin ⩾2.0 mg/dl | 2.12 (1.37 to 3.27) | 0.0007 | 2.24 (1.14 to 4.38) | 0.019 | 2.09 (1.12 to 3.90) | 0.020 |
| On ARDS diagnosis | ||||||
| Bilirubin | – | – | 1.19 (1.06 to 1.32) | 0.002 | 1.16 (1.05 to 1.28) | 0.003 |
| Log-bilirubin | – | – | 3.32 (1.57 to 7.06) | 0.002 | 3.29 (1.57 to 6.89) | 0.002 |
| Bilirubin ⩾2.0 mg/dl | – | – | 2.50 (1.23 to 5.08) | 0.012 | 2.54 (1.33 to 4.87) | 0.005 |
*Adjustment for age, gender, clinical risks for ARDS (trauma, pneumonia, aspiration, multiple transfusions), modified APACHE (Acute Physiology and Chronic Health Evaluation) III scores, septic shock, chronic liver diseases, history of alcohol use, history of steroid use and diabetes.
†Adjustment for age, gender, septic shock, chronic liver diseases, history of alcohol use, history of steroid use, diabetes, modified APACHE III scores, positive end-expiratory pressure and organ dysfunctions (respiratory, cardiovascular, renal and haematological).
ARDS, acute respiratory distress syndrome; ICU, intensive care unit.