| Generation of bronchi | Average increase in Ai/lobe (%) | ||||||||
| Third | Fourth | Fifth | Sixth | ||||||
| Baseline | After | Baseline | After | Baseline | After | Baseline | After | ||
| Right upper lobe | |||||||||
| Apical (B1) | 21.6 (3.0) | 26.7 (3.5)‡ | 10.0 (1.1) | 12.2 (1.3)‡ | 6.3 (0.7) | 8.0 (0.9)† | 3.7 (0.5) | 5.2 (0.4)‡ | |
| Posterior apical (B2) | 17.0 (1.6) | 22.0 (1.7)‡ | 8.7 (1.0) | 12.4 (1.0)‡ | 5.4 (0.7) | 7.1 (0.5) | 3.2 (0.3) | 4.7 (0.4)‡ | 41.8 (7.9) |
| Anterior apical (B3) | 24.2 (3.1) | 29.5 (2.9)‡ | 11.8 (1.4) | 15.3 (1.4)‡ | 8.2 (1.2) | 9.3 (1.0) | 4.6 (0.5) | 5.7 (0.6) | |
| Right middle lobe | |||||||||
| Medial (B4) | 11.0 (1.0) | 14.3 (1.1)‡ | 5.8 (0.5) | 7.7 (0.6)‡ | 3.7 (0.3) | 5.3 (0.4)‡ | 2.8 (0.3) | 4.2 (0.4)‡ | 39.1 (11.6) |
| Lateral (B5) | 20.5 (2.5) | 22.3 (2.1) | 11.3 (1.3) | 12.4 (1.0) | 6.9 (0.9) | 8.3 (0.7) | 4.7 (0.5) | 5.6 (0.4) | |
| Right lower lobe | |||||||||
| Anterior basal (B8) | 12.9 (1.9) | 17.0 (1.7)‡ | 7.2 (0.9) | 9.6 (1.3)† | 5.2 (0.6) | 5.8 (0.6) | 3.6 (0.4) | 4.3 (0.4)† | |
| Lateral basal (B9) | 13.0 (1.5) | 15.7 (1.4)† | 7.1 (1.1) | 8.3 (0.9 ) | 4.7 (0.7) | 5.6 (0.7) | 3.0 (0.3) | 4.0 (0.4)† | 37.8 (9.4) |
| Posterior basal (B10) | 15.4 (1.3) | 19.6 (1.9)‡ | 10.7 (1.4) | 13.2 (1.6)† | 7.1 (0.9) | 8.2 (1.0) | 4.6 (0.6) | 5.5 (0.7) | |
| Average increase in Ai/generation (%) | 32.5 (4.8) | 38.4 (6.4) | 38.0 (9.1) | 48.0 (11.2) | 39.3 (7.2)* | ||||
Data are shown as mean (SEM).
*Average of all measurements. † p<0.05 after tiotropium inhalation vs baseline. ‡ p<0.01 after tiotropium inhalation vs baseline.
Ai, inner luminal area of airway.