Number and proportion of tuberculosis cases reported with pulmonary and extrapulmonary tuberculosis, England and Wales 1999 and 2006
| 1999 | 2006 | % Increase in N | p Value(χ2 trend)* | |||
| N | % (95% CI) | N | % (95% CI) | |||
| ET lymph nodes | 1066 | 19 (18 to 20) | 1575 | 20 (19 to 21) | 47.7% | <0.001 |
| Pleural | 436 | 7.6 (7.0 to 8.4) | 641 | 8.0 (7.4 to 8.6) | 47.0% | 0.041 |
| IT lymph nodes | 371 | 6.5 (5.9 to 7.2) | 591 | 7.3 (6.8 to 7.9) | 59.3% | 0.001 |
| Gastrointestinal | 175 | 3.1 (2.7 to 3.6) | 315 | 3.9 (3.5 to 4.4) | 80.0% | 0.002 |
| Spine | 145 | 2.5 (2.2 to 3.0) | 268 | 3.3 (3.0 to 3.7) | 84.8% | 0.007 |
| Bone (not spine) | 140 | 2.5 (2.1 to 2.9) | 161 | 2.0 (1.7 to 2.3) | 15.0% | <0.001 |
| Genitourinary | 111 | 1.9 (1.6 to 2.3) | 135 | 1.7 (1.4 to 2.0) | 21.6% | 0.008 |
| Miliary TB | 38 | 0.7 (0.5 to 0.9) | 180 | 2.2 (1.9 to 2.6) | 373.7% | <0.001 |
| TB meningitis | 86 | 1.5 (1.2 to 1.9) | 165 | 2.0 (1.8 to 2.4) | 91.9% | <0.001 |
| CNS other | 41 | 0.7 (0.5 to 1.0) | 70 | 0.9 (0.7 to 1.1) | 70.7% | 0.240 |
| Cryptic disseminated | 31 | 0.5 (0.4 to 0.8) | 38 | 0.5 (0.3 to 0.6) | 22.6% | 0.075 |
| Laryngeal | 15 | 0.3 (0.2 to 0.4) | 13 | 0.2 (0.1 to 0.3) | −13.3% | 0.005 |
| Extrapulmonary only | 2310 | 41 (39 to 42) | 3480 | 43 (42 to 44) | 50.6% | <0.001 |
| Extrapulmonary with pulmonary involvement | 407 | 7.1 (6.5 to 7.8) | 725 | 9.0 (8.4 to 9.7) | 78.1% | <0.001 |
| Pulmonary only | 2923 | 51 (50 to 53) | 3742 | 47 (45 to 48) | 28.0% | <0.001 |
| All TB | 5704 | 100 | 8051 | 100 | 41.1% | Ref |
*χ2 trend test with one degree of freedom for changes across each year.
95% CI, 95% confidence interval for proportions using Wilson procedure; ET, extrathoracic; IT, intrathoracic; TB, tuberculosis; extrapulmonary only, all extrapulmonary tuberculosis sites without pulmonary involvement; pulmonary only, pulmonary tuberculosis without extrapulmonary involvement; all TB, all tuberculosis cases including those with unknown or other extrapulmonary sites of disease; Ref, reference group.