SPD-cholinergic (Protocol 1) | ΔSPDchol/β-adren (Protocol 2) | Sweat chloride-cholinergic | ||||||
(1) Test | p Value* | (2) Test | p Value* | p Value* | p Value* | |||
HC | −14.4 | 0.6 | −17.6 | 0.5 | −0.1 | 0.5 | 23.5 | 0.7 |
−16.6 to −8.1 | −27.2 to −13.4 | −3.6 to 5.2 | 11 to 42.4 | |||||
(9) | (9) | (8) | (10) | |||||
Hz | −16.0 | −16.8 | 1.8 | 18 | ||||
−20.5 to −6.7 | −19.6 to −8.3 | −0.6 to 6.4 | 13.5 to 28.5 | |||||
(10) | (10) | (7) | (10) | |||||
CFPS | −41.3 | 0.5 | −40.3 | 0.07 | 17.1 | 0.04 | 91 | 0.2 |
−55.9 to −37.4 | −51.2 to −28.5 | 12.3 to 19.8 | 68 to 103.5 | |||||
(10) | (5) | (8) | (8) | |||||
CFPI | −48.8 | −55.2 | 24.0 | 104 | ||||
−56.8 to −43.5 | −63.8 to −43.3 | 19.6 to 29.1 | 92.5 to 119.5 | |||||
(8) | (7) | (7) | (8) | |||||
HC + Hz | −14.5 | <0.001 | −17.6 | <0.001 | 1.5 | <0.001 | 21.5 | <0.001 |
−18.1 to −7.7 | −19.7 to −11.3 | −2.2 to 6.4 | 13.5 to 28.5 | |||||
(19) | (19) | (15) | (20) | |||||
CFPS + CFPI | −47.4 | −46.4 | 19.8 | 98.5 | ||||
−56.1 to −39.1 | −60.8 to −38.1 | 16.1 to 25.4 | 78.5 to 112 | |||||
(18) | (12) | (15) | (16) |
All data are given as medians, interquartile range (IQR) and number of subjects (n).
CFPI, pancreatic-insufficient CF patients; CFPS, pancreatic-sufficient CF patients; HC, healthy controls; Hz, heterozygotes; SPD, sweat gland potential difference; ΔSPDchol/β-adren, sweat gland potential difference recorded after cholinergic followed immediately by β-adrenergic stimulation minus SPD recorded after cholinergic stimulation alone.
*Wilcoxon rank sum test.