Table 2 Change in physiological outcome parameters in breathing training and control groups between the baseline and outcome (1 month) assessments in the intention to treat population

	Breathing training group			Control group			Mean (95% CI) between-group difference	p Value
	Baseline	1 month post-intervention	p Value	Baseline	1 month post-intervention	p Value	Mean (95% CI) between-group difference	p Value
FEV₁ (l)*	2.85 (0.83)	2.95 (0.83)	<0.001	2.82 (0.76)	2.97 (0.78)	<0.001	−0.06 (−0.13 to 0.00)	0.07
Methacholine PC₂₀†	4.13 (0.50 −to 17.0)	4.60 (0.85 to 17.0)	0.19	2.48 (0.17 to 17.0)	2.20 (0.28 to 17.0)	0.72	0.20 (−0.04 to 0.09)‡	0.54
Feno (ppb)†	25.5 (21.7 −to 29.9)	23.7 (20.0 to 28.2)	0.14	30.5 (25.6 to 36.3)	26.8 (22.6 to 31.8)	0.02	5.3 (−8.4 to 19.0)	0.44
Sputum eosinophils (%)†	1.21 (0.89 to 1.65)	1.21 (0.85 to 1.72)	0.97	1.88 (1.27 to 2.27)	1.52 (1.06 to 2.18)	0.28	−0.20 (−0.63 to 0.23)§	0.35
ETco₂ (kPa)*	4.26 (0.70)	4.40 (0.73)	0.09	4.25 (0.78)	4.32 (0.77)	0.43	0.08 (−0.15 to 0.30)	0.51
MV (l)†	13.49 (6.07)	11.21 (4.57)	<0.001	13.54 (5.44)	11.84 (4.82)	<0.005	−0.57 (−2.20 to 1.05)	0.49

*Mean (SD). †Geometric mean (transformed 95% confidence interval). ‡Doubling doses. §Fold change.
ETco₂, end tidal carbon dioxide; Feno, fraction of exhaled nitric oxide; FEV₁, forced expiratory volume in 1 s; MV, minute volume; PC₂₀, concentration of inhaled methacholine provoking a 20% fall in FEV₁.