Table 1 Clinical and pathological characteristics of the study population (22 patients with usual interstitial pneumonia)
Characteristic
Sex (M:F) (n)17:5
Status (dead/alive) (n)2:20
Age at biopsy (y)60.2 (6.2) (44–69)
Dust exposure (yes/no) (n)9:13
Smoker (yes/no) (n)12:10
Smoking (pack-years)23.3 (19.1) (0.45–64)
Follow-up (months) (median (range))9 (6–11)
Pathological features
    Fibroblastic foci score (%)
        14.6
        240.9
        313.6
        422.7
        54.6
        613.6
    Fibroblastic foci (AFF %) (median (range))8.4 (4.3–21.8)
    Fibrosis extension (AFib %)35.6 (7.4) (22–51.8)
    Inflammation score (%)
        153.8
        238.5
        37.7
    Inflammation (AIC %)3.0 (1.4) (1.2–6.6)
Spirometry at time of diagnosis
    Tlco (% predicted)53.7 (12.7) (23–77)
    FEV1 (% predicted)72.9 (15.7) (42–109)
    FVC (% predicted)69.5 (13.6) (49–97)
    VC (% predicted)71.1 (12.7) (47–94)
    TLC (% predicted)67.1 (12.9) (48–91)
    RV (% predicted)67.7 (25.5) (31–125)
  • Values are mean (SD) (range) unless otherwise stated. For normally distributed quantitative variables, values are mean (SD) (range); for not normally distributed quantitative variables, median range (IQR) are shown; for categorical variables, percentage distributions are shown.

  • AFF, fibroblastic foci area; AFib, fibrotic area; AIC, inflammatory cells area; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; RV, residual volume; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; VC, vital capacity.