Predictors of early mortality (death within 12 months of right heart catheterisation): mortality as determined by logistic regression for continuous parameters and a priori threshold values
| OR (95% CI) | p Value | |
| Right heart catheterisation | ||
| PVR (continuous; WU) | 1.30 (1.11 to 1.52) | 0.001*† |
| PVR ⩾3 | 3.00 (0.61 to 14. 86) | 0.18 |
| PVR ⩾3.56 | 2.71 (0.68 to 10.72) | 0.16 |
| PVR ⩾6.23 | 8.15 (2.38 to 27.87) | 0.001*† |
| mPAP (continuous; mm Hg) | 1.05 (1.00 to 1.01) | 0.03 |
| mPAP ⩾17 | 1.82 (0.20 to 16.78) | 0.60 |
| mPAP ⩾25 | 3.00 (0.61 to 14.86) | 0.18 |
| mPAP ⩾35 | 1.78 (0.58 to 5.40) | 0.31 |
| mPAP ⩾45 | 3.91 (1.05 to 14.50) | 0.04 |
| mRAP (continuous; mmHg) | 0.97 (0.84 to 1.11) | 0.65 |
| mLAP | 0.93 (0.84 to 1.04) | 0.19 |
| Cardiac output (l/min) | 0.59 (0.33 to 1.03) | 0.06 |
| Echocardiography | ||
| RVSP (mm Hg)‡ | 1.02 (0.99 to 1.06) | 0.23 |
| RA dilation | 2.55 (0.82 to 7.89) | 0.10 |
| RV dilation | 4.13 (1.25 to 13.64) | 0.02* |
| Echocardiographic evidence of PH§ | 3.00 (0.61 to 14.86) | 0.18 |
| Pulmonary function | ||
| Tlco % predicted‡ | 0.96 (0.92 to 1.01) | 0.12 |
| FVC % predicted‡ | 0.99 (0.97 to 1.02) | 0.58 |
| CPI | 1.03 (0.99 to 1.08) | 0.14 |
| Pao2 (kPa)‡ | 0.71 (0.51 to 0.98) | 0.04 |
| Clinical | ||
| Age | 1.00 (0.95 to 1.04) | 0.93 |
| Male gender | 1.07 (0.35 to 3 to28) | 0.90 |
| Time from presentation (months) | 1.01 (1.00 to 1.02) | 0.05 |
| Coronary artery disease | 1.94 (0.40 to 9.49) | 0.42 |
| WHO class | 2.67 (1.21 to 5.88) | 0.02* |
| Exclusion of IPF patients | 8.04 (1.72 to 37.59) | 0.008 |
| Exclusion of CTD-related fibrosis patients | 9.92 (2.30 to 42.85) | 0.002 |
| Exclusion of idiopathic NSIP patients | 9.9 (2.68 to 36.53) | 0.001 |
| Exclusion of sarcoidosis patients | 8.89 (2.34 to 33.81) | 0.001 |
*Remains significant following adjustment for age, gender, CPI and diagnosis of IPF (PVR: OR 1.41, 95% CI 1.17 to 1.71, p<0.001; PVR ⩾6.23: OR 11.09, 95% CI 2.54 to 48.36, p = 0.001; RV dilatation: OR 6.19, 95% CI 1.47 to 26.02, p = 0.01; WHO class: OR 2.63, 95% CI 1.03 to 6.68, p = 0.04).
†Remains significant for patients with mLAP <15 mm Hg (PVR: OR 1.25, 95% CI 1.06 to 1.47, p = 0.007; PVR ⩾6.23: OR 6.5, 95% CI 1.71 to 24.68, p = 0.006).
‡No a priori threshold value significantly predicted early mortality.
§Patients with RVSP ⩾40 mm Hg or right atrial or right ventricular dilation or right ventricular dysfunction.
CI, confidence interval; CPI, composite physiological index; CTD, connective tissue disease; FVC, forced vital capacity; IPF, idiopathic pulmonary fibrosis; mLAP, mean left atrial pressure; mPAP, mean pulmonary artery pressure; mRAP, mean right atrial pressure; NSIP, non-specific interstitial pneumonia; OR, odds ratio; Pao2, arterial oxygen tension; PH, pulmonary arterial hypertension; PVR, pulmonary vascular resistance; RA, right atrial; RV, right ventricular; RVSP, right ventricular systolic pressure; Tlco, transfer factor for carbon monoxide; WHO, World Health Organization; WU, Wood units.