Table 6 Modifications of the CURB65 and CRB65 scores for prediction of 30 day mortality and need for mechanical ventilation and/or inotropic support
PPV (%)NPV (%)Sensitivity (%)Specificity (%)AUCp Value
Prediction of 30 day mortality
    CURB65 score20.995.770.180.40.76 (0.74–0.79)<0.0001
    CUR65 + systolic BP<90 mm Hg26.695.365.479.40.79 (0.76–0.81)<0.0001
    CRB65 score28.694.047.487.40.74 (0.71–0.77)<0.0001
    CR65 + systolic BP<90 mm Hg36.893.640.292.60.76 (0.73–0.79)<0.0001
Prediction of need for mechanical ventilation and/or inotropic support
    CURB65 score22.795.771.881.00.78 (0.75–0.81)<0.0001
    CUR65 + systolic BP<90 mm Hg25.195.063.179.70.79 (0.76–0.81)<0.0001
    CRB65 score30.493.647.687.60.77 (0.74–0.79)<0.0001
    CR65 + systolic BP<90 mm Hg36.892.937.992.60.77 (0.74–0.80)<0.0001
  • AUC, area under the receiver operator characteristic curve; BP, blood pressure; NPV, negative predictive value; PPV, positive predictive value.