| Total group | Normal LDH | Increased LDH | p Value | |
| No of male patients | 178 | 148 | 30 | – |
| Age (y) | 66.0 (9.2) | 65.7 (9.0) | 67.7 (10.4) | 0.2832 |
| FEV1 (% predicted) | 39.9 (14.2) | 39.7 (13.6) | 40.7 (17.5) | 0.7350 |
| Tlco (% predicted) | 48.2 (18.3) | 48.0 (18.6) | 49.8 (17.2) | 0.6719 |
| MRC dyspnoea grade | 3.8 (1.1) | 3.7 (1.2) | 4.4 (0.9) | 0.0050 |
| BMI (kg/m2) | 25.1 (4.6) | 24.8 (4.6) | 26.4 (4.8) | 0.0867 |
| FFMI (kg/m2) | 17.3 (2.2) | 17.2 (2.1) | 17.8 (2.3) | 0.1589 |
| 6MWD (m) | 404.3 (130.1) | 417.8 (128.4) | 333.8 (117.2) | 0.0016 |
| 6MWD (% predicted) | 60.3 (18.9) | 61.9 (18.6) | 52.1 (19.0) | 0.0114 |
| Borg score D (points) | 4.5 (2.2) | 4.4 (2.2) | 5.1 (2.1) | 0.1124 |
| Borg score F (points) | 3.8 (2.3) | 3.9 (2.3) | 3.6 (2.4) | 0.6004 |
| LDH (U/l) | 404.1 (96.0) | 372.8 (57.5) | 559.4 (98.8) | 0.0001 |
Values are mean (SD).
6MWD, 6 min walking distance; BMI, body mass index; D, dyspnoea; F, fatigue; FEV1, forced expiratory volume in 1 s; FFMI, fat free mass index; LDH, lactate dehydrogenase; MRC, Medical Research Council; Tlco, carbon monoxide transfer factor; U/l, micromoles per minute/litre.