| N | LS Mean (SE)* | Varenicline vs NRT | ||||
| Difference (SE) | 95% CI | p Value | Effect size† | |||
| Varenicline | ||||||
| Smoking satisfaction | 361 | 2.73 (0.09) | –0.54 (0.12) | –0.77 to –0.31 | <0.001 | –0.43 |
| Psychological reward | 361 | 2.30 (0.07) | –0.32 (0.10) | –0.51 to –0.13 | 0.001 | –0.26 |
| Enjoyment of respiratory tract sensations | 358 | 2.04 (0.08) | –0.39 (0.11) | –0.60 to –0.17 | <0.001 | –0.25 |
| Craving reduction | 360 | 3.62 (0.10) | –0.52 (0.14) | –0.79 to –0.24 | <0.001 | –0.32 |
| Aversion | 361 | 1.76 (0.07) | –0.07 (0.09) | –0.25 to 0.11 | 0.436 | –0.08 |
| NRT | ||||||
| Smoking satisfaction | 354 | 3.27 (0.08) | ||||
| Psychological reward | 354 | 2.61 (0.07) | ||||
| Enjoyment of respiratory tract sensations | 353 | 2.42 (0.08) | ||||
| Craving reduction | 354 | 4.14 (0.10) | ||||
| Aversion | 354 | 1.83 (0.06) | ||||
NRT, nicotine replacement therapy.
N, total number of participants contributing to the repeated measures analysis. To be included subjects must have completed a questionnaire at baseline and at one or more post-baseline visits. This includes those who smoked during the first week of treatment, which was before the target quit date.
*Higher scores indicate greater intensity of smoking effects. Response scale: 1 (not at all) to 7 (extreme).
†Effect size, LS mean difference divided by the pooled SD at baseline (pooled by centre).