| OSAS with EDS (n = 20) | OSAS without EDS (n = 15) | Differences in after−before CPAP between patients with and without EDS (95% CI) | p Value | |||
| Before CPAP | After CPAP | Before CPAP | After CPAP | |||
| Glucose (mg/dl) | 114 (19) | 111 (22) | 101 (6) | 100 (9) | −2.1 (−7.8 to 3.5) | 0.44 |
| Triglycerides (mg/dl) | 206 (114) | 218 (121) | 157 (54) | 149 (61) | 20.8 (−18.6 to 60.3) | 0.29 |
| Cholesterol (mg/dl) | 224 (34) | 211 (29)* | 214 (41) | 206 (41) | −4.1 (−21.7 to 13.5) | 0.63 |
| HDLc (mg/dl) | 46 (10) | 44 (7) | 53 (10) | 50 (9) | 1.91 (−1.6 to 5.4) | 0.27 |
| Insulin (μU/ml) | 14.8 (7.9) | 12.0 (5.0)* | 9.0 (4.8) | 9.5 (4.7) | −3.3 (−6.5 to −0.2) | 0.03 |
| HOMA index | 4.4 (2.4) | 3.3 (1.3)** | 2.3 (1.2) | 2.4 (1.2 ) | −1.2 (−2.1 to −0.3) | 0.007 |
| TSH (uUI/ml) | 1.2 (0.5) | 1.1 (0.6) | 1.4 (0.6) | 1.4 (0.7) | 0.01 (−0.22 to 0.25) | 0.89 |
| Cortisol (mg/dl) | 13.1 (5.1) | 12.3 (4.9) | 15.0 (3.8) | 12.5 (2.4) | 1.6 (−1.2 to 4.5) | 0.26 |
| GH (ng/ml) | 0.42 (0.28) | 0.45 (0.37) | 0.14 (0.11) | 0.07 (0.05) | 0.09 (−0.11 to 0.29) | 0.35 |
| IGF-1 (ng/ml) | 122 (99) | 145 (134)* | 113 (25) | 127 (28) | 14.1 (−13.3 to 41.5) | 0.30 |
*p<0.05, **p<0.01 versus before CPAP.
CPAP, continuous positive airway pressure; EDS, excessive daytime sleepiness; GH, growth hormone; HDLc, high density lipoprotein cholesterol; HOMA, homeostasis model assessment; IGF-1, insulin-like growth factor I; OSAS, obstructive sleep apnoea syndrome; TSH, thyrotropin.