Table 4 Change in daytime gas exchange, weight and subjective sleep quality following 3 months of positive pressure in the three treatment groups
OutcomeChange in CPAP group Mean (SD)Change in BVS group Mean (SD)Mean difference between treatments(95% CI)p Value†
Paco2 (mm Hg)−5.8 (8.4)*−6.9 (6.7)*1.04 (−4.5 to 6.6)0.7
Awake Spo2 (%)6 (3)*8 (5)*1.9 (−5. 2 to 1.3)0.24
Bicarbonate (mmol/l)−2.3 (8.5)*−2.5 (2.5)*0.2 (−4.2 to 4.6)0.93
Weight loss (kg)−4.9 (7.8)*−5.6 (9.4)*0.7 (−5.2 to 6.5)0.82
Mean nightly therapy use (h)5.8 (2.4)6.1 (2.1)0.33 (−1.8 to 1.2)0.66
ESS−6 (8)*−9 (5)**2.89 (−1.78 to 7.56)0.21
PSQI−1.93 (3.5)−5.6 (3.9)**3.67 (0.82 to 6.5)0.013
  • BVS, bilevel ventilatory support; CPAP, continuous positive airway pressure; Paco2, arterial carbon dioxide tension; Spo2, oxygen saturation; ESS, Epworth Sleepiness Scale; PSQI, Pittsburgh Sleep Quality Index.

  • *p<0.05, **p<0.001, within group changes from baseline.

  • †p Value denotes mean difference between CPAP and BVS treatment groups using unpaired t tests.