| Baseline | 2 h | 4 h | |
| Pao2 (kPa) | |||
| NS | 13.5 (12.0–15.0) | 11.3 (9.3–13.3) | 9.7 (8.0–11.4)* |
| IL-1Ra | 12.9 (12.2–13.6) | 12.4 (10–14.8) | 11.6 (9.5–13.7) |
| Paco2 (kPa) | |||
| NS | 4.9 (4.2–5.6) | 5.7 (5.2–6.2) | 5.3 (3.7–6.9) |
| IL-1Ra | 5.4 (4.2–6.6) | 5.7 (4.5–6.9) | 6.1 (4.8–7.4) |
| pH | |||
| NS | 7.43 (7.37–7.49) | 7.39 (7.36–7.42) | 7.32 (7.24–7.40) |
| IL-1Ra | 7.41 (7.35–7.47) | 7.42 (7.34–7.48) | 7.39 (7.33–7.45) |
| Respiratory system compliance (ml/cm H2O) | |||
| NS | 0.34 (0.32–0.36) | 0.28 (0.25–0.31) | 0.26 (0.22–0.30)* |
| IL-1Ra | 0.33 (0.29–0.37) | 0.31 (0.28–0.34) | 0.30 (0.27–0.33) |
Data are mean (SD).
Pao2. Paco2, arterial oxygen and carbon dioxide tensions; NS, normal saline; IL-1Ra, IL-1 receptor antagonist.
*p<0.05 vs baseline value in the same group.