IL-1β (pM) | TNFα (pM) | CXCL8 (nM) | MPO (mg/ml) | LTB4 (nM) | GROα (nM) | Sputum macrophages(106/ml) | Sputum neutrophils(106/ml) | Median CV (IQR) | |
Median | 43.3 | 2.07 | 3.6 | 1.8 | 6.1 | 12.3 | 0.29 | 2.65 | |
IQR | 7.5–413 | 0.2–55 | 1.4–14.4 | 1.1–3.5 | 1.5–18.6 | 5–19.5 | 0.13–0.75 | 1–6.4 | |
CV calculated from raw data | 53.5 | 407.8 | 145.4 | 102 | 99.8 | 60.9 | 100 | 115.4 | 101% (90-123) |
CV calculated using 5-day rolling mean | 52.15 | 234.6 | 131 | 92.15 | 78.2 | 58.5 | 110 | 89.4 | 91% (73–115) |
The median biomarker concentration (and IQR) is calculated from all measurements for all patients. In order to calculate the inter-patient CVs, the mean logged concentrations were calculated for each biomarker in each patient (either using daily data or data from the first 5-day rolling mean).
IL-1β, interleukin 1β; TNFα, tumour necrosis factor α; CXCL8, interleukin 8; MPO, myeloperoxidase; LTB4, leucotriene B4; GROα, growth-related oncogene α; IQR, interquartile range.