Visit | Procedures and measurements |
Screening | Informed consent, medical history, physical examination, spirometry, inclusion/exclusion criteria, enrolment |
Baseline | Feno, spirometry, saliva, urine, induced sputum |
Aspirin provocation (3–10 days after visit 2) | Before: Feno; spirometry; saliva; urine; blood (LT and CC-16) |
During: Spirometry; saliva and urine every hour | |
After: Blood and saliva up to 2 h after end of provocation* and urine up to 3 h after |
*Time from inhalation of dose of lysine-aspirin causing ⩾20% fall in FEV1 for AIA group and after highest dose in ATA group.
AIA, aspirin-intolerant asthma; ATA, asthma-tolerant asthma; CC-16, Clara cell protein-16; Feno, fraction of exhaled nitric oxide; FEV1, forced expiratory volume in 1 s; LT, leukotriene; PD20, dose provoking a fall in FEV1 of 20% or more.