Healthy volunteers | CF patients | ||
Children (age ⩽16 years) | Adults (age ⩾17 years) | ||
N | 12 | 48 | 33 |
M/F | 7/5 | 19/29 | 21/12 |
Mean (range) age (years) | 11 (6–16) | 33 (19–58) | 30 (17–49) |
Mean (SD) FEV1 (% predicted) | 95 (11) | 102 (12) | 66 (23)* |
LCI | |||
Mean (SD) | 6.3 (0.5) | 6.7 (0.4) | 13.1 (3.8)* |
Range | 5.6–7.1 | 6.0–7.8 | 6.3–20.4 |
Mean (SD) CV% | 5.4 (3.8) | 3.6 (2.1) | 4.5 (2.7) |
FEV1, forced expiratory volume in 1 s; CV%, coefficient of variation (%) for intra-visit repeats.
*p<0.001 vs adult healthy volunteers (Mann-Whitney U test).