Table 2 Baseline induced cytology and inflammatory biomarker levels
VariableMedian (IQR)
Induced sputum cell counts and proportion (%)
    Total cell count (×106)1.4 (0.8–4.3)
    Macrophages (×104)196.5 (101.3–235.0)
    Macrophages (%)49.5 (30.5–57.5)
    Neutrophils (×104)129.8 (60.0–186.5)
    Neutrophils (%)35.5 (14.5–48.3)
    Eosinophils (×104)6.4 (2.0–16.3)
    Eosinophils (%)1.5 (0.6–5.0)
    Lymphocytes (×104)2.5 (1.0–5.5)
    Lymphocytes (%)0.7 (0.3–1.1)
    Bronchial epithelial cells (×104)44.0 (12.0–60.3)
    Bronchial epithelial cells (%)10.0 (8.0–316.0)
Sputum mediators
    MPO (ng/ml)179.0 (73.5–276.0)
    LTB4 (pg/ml)47.8 (32.6–80.4)
    IL8 (ng/ml)1.9 (0.8–5.3)
    TNFα (pg/ml)11.4 (4.6–46.5)
    IFNγ (pg/ml)19.8 (4.9–71.6)
Exhaled nitric oxide
    FeNO (ppb)18.3 (10.1–33.1)
Serum biomarkers
    hs-CRP (mg/l)1.68. (0.5–3.8)
    sICAM (ng/ml)209.4 (185.7–245.4)
    IL5 (pg/ml)7.3 (1.9–26.4)
    IL8 (pg/ml)14.3 (0.6–24.0)
    TNFα (pg/ml)1.1 (0.7–1.8)
    IL6 (pg/ml)1.1 (0.7–3.1)
  • CRP, C-reactive protein; IFN, interferon; IL, interleukin; LT, leucotriene; MPO, myeloperoxidase; NO, nitric oxide; ppb, parts per billion; sICAM, soluble intercellular adhesion molecule; TNFα, tumour necrosis factor-α.