Variable | Median (IQR) |
Induced sputum cell counts and proportion (%) | |
Total cell count (×106) | 1.4 (0.8–4.3) |
Macrophages (×104) | 196.5 (101.3–235.0) |
Macrophages (%) | 49.5 (30.5–57.5) |
Neutrophils (×104) | 129.8 (60.0–186.5) |
Neutrophils (%) | 35.5 (14.5–48.3) |
Eosinophils (×104) | 6.4 (2.0–16.3) |
Eosinophils (%) | 1.5 (0.6–5.0) |
Lymphocytes (×104) | 2.5 (1.0–5.5) |
Lymphocytes (%) | 0.7 (0.3–1.1) |
Bronchial epithelial cells (×104) | 44.0 (12.0–60.3) |
Bronchial epithelial cells (%) | 10.0 (8.0–316.0) |
Sputum mediators | |
MPO (ng/ml) | 179.0 (73.5–276.0) |
LTB4 (pg/ml) | 47.8 (32.6–80.4) |
IL8 (ng/ml) | 1.9 (0.8–5.3) |
TNFα (pg/ml) | 11.4 (4.6–46.5) |
IFNγ (pg/ml) | 19.8 (4.9–71.6) |
Exhaled nitric oxide | |
FeNO (ppb) | 18.3 (10.1–33.1) |
Serum biomarkers | |
hs-CRP (mg/l) | 1.68. (0.5–3.8) |
sICAM (ng/ml) | 209.4 (185.7–245.4) |
IL5 (pg/ml) | 7.3 (1.9–26.4) |
IL8 (pg/ml) | 14.3 (0.6–24.0) |
TNFα (pg/ml) | 1.1 (0.7–1.8) |
IL6 (pg/ml) | 1.1 (0.7–3.1) |
CRP, C-reactive protein; IFN, interferon; IL, interleukin; LT, leucotriene; MPO, myeloperoxidase; NO, nitric oxide; ppb, parts per billion; sICAM, soluble intercellular adhesion molecule; TNFα, tumour necrosis factor-α.