Table 4 Autoantibody assay panel sensitivity by tumour stage
GroupSubgroupAutoantibody positivity population (panel of 7)
Stage IStage IIStage IIIStage IV
SCLCNumber +ve002/37/11
n = 14% +ve (95% CI)67 (9 to 99)64 (31 to 89)
SCLCPre-TxNumber +ve001/17/11
n = 12% +ve (95% CI)100 (3 to 100)64 (31 to 89)
NSCLCNumber +ve4/54/410/1321/27
n = 49% +ve (95% CI)80 (28 to 99)100 (40 to 100)77 (46 to 95)78 (58 to 91)
NSCLCPre-TxNumber +ve3/33/35/715/20
n = 33% +ve (95% CI)100 (29 to 100)100 (29 to 100)71 (29 to 96)75 (51 to 91)
  • Number and percentage positivity (% +ve) with 95% confidence interval (95% CI) in each tumour stage (where known) using panel 1/7. Stage taken at diagnosis date follows from T,N,M-staging.

  • SCLC, small cell lung cancer; NSCLC, non-small cell lung cancer; 95% CI denotes the 95% confidence interval; Pre-Tx, pretreatment samples.

  • Samples taken within 6 months of diagnosis for NSCLC, and within 4 months of diagnosis for SCLC.