Table 3 Autoantibody panel sensitivity by lung cancer subgroup
GroupAutoantibody positivity population (panel of 7)
All samplesSubset 0–1Subset 0–6
0–36 months0–1 month Pre-Tx0–6 months Pre-Tx
SCLC
    Number +ve15/225/89/13
    % +ve (95% CI)68 (45 to 86)63 (24 to 91)69 (39 to 91)
NSCLC
Squamous
    Number +ve23/255/511/12
    % +ve (95% CI)92 (74 to 99)100 (48 to 100)92 (62 to 100)
Adeno
    Number +ve27/355/713/16
    % +ve (95% CI)77 (60 to 90)71 (29 to 96)81 (54 to 96)
NOS
    Number +ve14/220/22/6
    % +ve (95% CI)64 (41 to 83)0 (0 to 84)33 (4 to 78)
All LC
    Number +ve79/10415/2235/47
    % +ve (95% CI)76 (67 to 84)68 (45 to 86)74 (60 to 86)
p Value from χ2 test*0.1070.2110.285
  • Number and percentage positivity (% +ve) with 95% confidence interval (95% CI) in each patient group using panel 1/7. Analysis repeated on two subset sample populations taking only pretreatment (pre-Tx) samples up to 1 month and 6 months from diagnosis.

  • 2 Test across cancer subgroups noting that NOS was pooled with adeno in the subset analyses owing to small numbers.

  • All LC, all lung cancer samples tested; SCLC, small cell lung cancer; NSCLC, non-small cell lung cancer; Adeno, adenocarcinoma; Squamous, squamous cell carcinoma; NOS, not otherwise specified.