| CA 125 | CA 15-3 | CA 19-9 | CYFRA 21-1 | |
| Number of studies | 10 | 11 | 7 | 18 |
| Number of patients with MPE/non-MPE | 512/801 | 819/966 | 598/488 | 1152/1122 |
| Sensitivity (95% CI) | 0.48 (0.44 to 0.53) | 0.51 (0.47 to 0.54) | 0.25 (0.21 to 0.28) | 0.55 (0.52 to 0.58) |
| Heterogeneity* (p) | 212.65 (<0.001) | 76.46 (<0.001) | 99.32 (<0.001) | 246.24 (<0.001) |
| Specificity (95% CI) | 0.85 (0.83 to 0.88) | 0.96 (0.95 to 0.97) | 0.96 (0.94 to 0.98) | 0.91 (0.90 to 0.93) |
| Heterogeneity (p) | 260.86 (<0.001) | 72.58 (<0.001) | 60.97 (<0.001) | 177.54 (<0.001) |
| PLR (95% CI) | 5.96 (2.27 to 15.68) | 11.69 (5.05 to 27.07) | 10.42 (2.66 to 40.78) | 6.55 (3.09 to 13.88) |
| Heterogeneity (p) | 311.44 (<0.001) | 55.65 (<0.001) | 36.90 (<0.001) | 313.76 (<0.001) |
| NLR (95% CI) | 0.54 (0.38 to 0.78) | 0.52 (0.43 to 0.62) | 0.70 (0.55 to 0.88) | 0.43 (0.34 to 0.54) |
| Heterogeneity (p) | 109.99 (<0.001) | 63.21 (<0.001) | 69.30 (<0.001) | 198.87 (<0.001) |
| DOR (95% CI) | 19.61 (6.25 to 61.52) | 24.74 (10.50 to 58.28) | 19.88 (4.19 to 94.24) | 16.24 (9.60 to 27.49) |
| Heterogeneity (p) | 49.68 (<0.001) | 36.96 (<0.001) | 32.75 (<0.001) | 47.23 (<0.001) |
| AUC (SEM) | 0.88 (0.06) | 0.73 (0.07) | 0.78 (0.16) | 0.83 (0.03) |
*Q value.
CI, confidence interval; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under curve; SEM, standard error of mean.