Table 4 Mean (SD) changes in lung function and breathing patterns after 3 months of treatment
BaselineAfter rehabChange within groupBetween group difference in change (95% CI)
FEV1 (l)
    N+R0.90 (0.38)0.89 (0.39)−0.01−0.04 (−0.1 to 0.1)
    R0.78 (0.30)0.81 (0.29)0.03
VC (l)
    N+R2.89 (0.82)2.98 (0.89)0.09−0.07 (−0.3 to 0.2)
    R2.47 (0.73)2.62 (0.86)0.15
TLC (% pred)
    N+R125 (18)125 (18)0.20.1 (−5.5 to 5.7)
    R123 (19)123 (16)0.4
RV%TLC
    N+R62 (8)62 (10)−0.11 (−3 to 5)
    R66 (10)64 (9)−2.2
Pimax (kPa)
    N+R5.0 (2.6)6.4 (2.3)1.40.8 (−0.2 to 1.8)
    R5.3 (2.2)5.9 (2.3)0.5
Ve (l/min)
    N+R9.8 (3.0)10.6 (3.1)0.81.4 (0.3 to 2.4)*
    R9.0 (1.9)8.6 (2.3)−0.4
Vt (ml)
    N+R506 (144)560 (135)5453 (−9 to 116)
    R524 (129)519 (147)−6
BF (breaths/min)
    N+R20 (5)19 (5)0.60.5 (−1.4 to 2.3)
    R18 (4)17 (5)0.2
  • BF, breathing frequency during quiet breathing; FEV1, forced expiratory volume in 1 s; N+R, non-invasive positive pressure ventilation (NIPPV) + rehabilitation; Pimax, maximal inspiratory pressure; R, rehabilitation alone; RV%TLC, residual volume as a percentage of TLC; TLC, total lung capacity as a percentage of predicted value; VC, vital capacity; Ve, minute ventilation during quiet breathing, Vt, tidal volume during quiet breathing. *Significant difference in change between groups.