Table 2 Microarray expression of the different cytokines in the quadriceps of the COPD patients with respect to the control subjects
CytokineControl subjectsCOPD patientsp Value
CTLA (au)0.0281 (0.0047)0.0192 (0.0122)0.075
IL2 (au)0.0143 (0.0001)0.0129 (0.0067)0.120
IL6R (au)0.0125 (0.0009)0.0143 (0.0048)0.731
IL7 (au)0.0105 (0.0002)0.0108 (0.0036)0.629
IL15 (au)0.0204 (0.0029)0.0205 (0.0131)0.891
MIP-1α (au)0.0127 (0.0001)0.0095 (0.0025)0.005
TGFβ (au)0.0078 (0.0002)0.0044 (0.0012)0.005
VCAMP-1 (au)0.0142 (0.0029)0.0128 (0.0043)0.075
VEGF (au)0.0102 (0.0058)0.0081 (0.0051)0.036
Apol/Fas (au)0.0193 (0.0025)0.0159 (0.0098)0.120
GM-CSF (au)0.0149 (0.0006)0.0155 (0.0053)0.235
IL3 (au)0.0137 (0.0010)0.0120 (0.0030)0.005
IL6 (au)0.0088 (0.0051)0.0120 (0.0050)0.945
IL10 (au)0.0110 (0.0030)0.0111 (0.0022)0.331
IL17 (au)0.0121 (0.0012)0.0114 (0.0052)0.019
MIP-1β (au)0.0119 (0.0021)0.0109 (0.0028)0.044
MIP-4 (au)0.0193 (0.0044)0.0184 (0.0072)0.183
IFNγ (au)0.0096 (0.0017)0.0045 (0.0056)0.036
RANTES (au)0.0144 (0.0033)0.0106 (0.0071)0.160
Leptin (au)0.0208 (0.0022)0.0195 (0.0096)0.235
IL5 (au)0.0037 (0.0067)0.0040 (0.0073)0.367
IL12 (au)0.0414 (0.0102)0.0393 (0.0175)0.783
MIP-5 (au)0.0118 (0.0023)0.0140 (0.0049)0.367
TNFα (au)0.0189 (0.0019)0.0113 (0.0055)<0.0001
TNFα R I (au)0.0164 (0.0004)0.0184 (0.0051)0.891
TNFα R II (au)0.0189 (0.0022)0.0236 (0.0092)0.075
IL1α (au)0.0015 (0.0015)0.0030 (0.0028)0.265
IL1β (au)0.0089 (0.0036)0.0086 (0.0051)0.103
IL1Rα (au)0.0137 (0.0062)0.0166 (0.0049)0.731
IL4 (au)0.0222 (0.0051)0.0226 (0.0098)0.999
IL8 (au)0.0129 (0.0024)0.0134 (0.0016)0.139
Eotaxin (au)0.0208 (0.0020)0.0202 (0.0064)0.075
EGF (au)0.0231 (0.0005)0.0209 (0.0048)0.019
MMP3 (au)0.0166 (0.0014)0.0228 (0.0101)0.120
ICAMP-1 (au)0.0124 (0.0039)0.0135 (0.0059)0.731
IP-10 (au)0.0122 (0.0051)0.0166 (0.0078)0.367
  • Data are presented as median and (interquartile range).

  • au, arbitrary units; COPD, chronic obstructive pulmonary disease; CTLA, cytotoxic T lymphocyte antigen; EGF, epidermal growth factor; GM–CSF, granulocyte-macrophage–colony stimulating factor; ICAM, intercellular adhesion molecule; IFN, interferon; IL, interleukin; IP-10, interferon γ inducible protein 10; MIP, macrophage inflammatory protein; MMP, matrix metalloproteinases; R, receptor; RANTES, regulated upon activation normal T cell expressed and secreted; TGF, transforming growth factor; TNF, tumour necrosis factor; VCAMP; vascular cell adhesion molecule; VEGF, vascular endothelial growth factor.