| Control subjects (n = 7) Mean (SD) [95% CI] | COPD patients (n = 19) Mean (SD) [95% CI] | Statistical data Mean difference [95% CI], p value | |
| Age (y) | 63 (8) [52 to 74] | 64 (8) [61 to 68] | −1 [−12 to +9], p = 0.742 |
| BMI (kg/m2) | 28 (1.7) [25.8 to 30] | 22.5 (5.2) [20 to 25] | +5.5 [+2.5 to +8.4], p = 0.001 |
| FFMI (kg/m2) | 19.1 (1.2) [17.6 to 20.6] | 16 (2.7) [14.6 to 17.4] | +3.1 [+1.3 to +4.9], p = 0.002 |
| FEV1 (% pred) | 110 (18) [87 to 134] | 33 (13) [27 to 40] | +77 [+54 to +100], p<0.0001 |
| FVC (% pred) | 100 (12) [85 to 114] | 69 (19) [60 to 78] | +31 [+16 to +46], p = 0.001 |
| RV (%) | 112 (1) [109 to 115] | 202 (50) [178 to 226] | −89 [−113 to −65], p<0.0001 |
| TLC (% pred) | 104 (4) [92 to 115] | 120 (15) [113 to 127] | −17 [−26 to −7], p = 0.002 |
| DLco (% pred) | 93 (2) [88 to 98] | 47 (27) [32 to 61] | +46 [+32 to +61], p<0.0001 |
| KCO (% pred) | 85 (5) [72 to 98] | 57 (29) [41 to 72] | +28 [+12 to +45], p = 0.002 |
| Pao2 (kPa) | NA | 9.2 (1.4) [9.8 to 8.5] | |
| Paco2 (kPa) | NA | 5.5 (0.9) [5.9 to 5.0] | |
| Vo2max (% pred) | NA | 55 (7) [36 to 74] | |
| Wrmax (% pred) | NA | 45 (8) [22 to 67] | |
| QMVC (kg) | 40.4 (6.2) [32.7 to 48] | 29.9 (8.9) [23.9 to 35.9] | +10.5 [+1.9 to +19], p = 0.02 |
| Q twitch tension (kg) | 10.2 (2.4) [7.2 to 13.2] | 8.5 (2.7) [6.7 to 10.2] | +1.7 [−1.4 to +4.8], p = 0.238 |
| Type I fibres (%) | 43 (10.6) [26 to 60] | 29 (7.4) [24 to 33] | +14 [−1 to +30], p = 0.03 |
| Type II fibres (%) | 57 (10.6) [40 to 74] | 71 (7.3) [66 to 76] | −14 [−30 to +2], p = 0.03 |
Data are presented as mean (SD) and [95% CI].
BMI, body mass index; COPD, chronic obstructive pulmonary disease; DLco, carbon monoxide transfer; FEV1, forced expiratory volume in 1 s; FFMI, fat free mass index; FVC, forced vital capacity; KCO, Krogh transfer factor; MVC, maximal velocity contraction; NA, not available; Pao2, arterial oxygen partial pressure; Paco2, arterial carbon dioxide partial pressure; pred, predicted; Q, quadriceps; RV, residual volume; TLC, total lung capacity; Vo2max, peak exercise oxygen uptake; Wrmax, maximal mechanical power output.