IPAH(n = 96) | Distal CTEPH(n = 35) | Proximal CTEPH(n = 68) | p Value (ANOVA) | |
---|---|---|---|---|
Values are mean (SD). | ||||
CTEPH, chronic thromboembolic pulmonary hypertension; FEV1, forced expiratory volume in1 s; FVC, forced vital capacity; IPAH, idiopathic pulmonary arterial hypertension; Kco, carbon monoxide transfer coefficient; mPAP, mean pulmonary artery pressure; RAP, resting arterial pressure; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; TPR, total pulmonary resistance. | ||||
Significant pairwise comparisons are listed below: | ||||
*p = 0.02 (IPAH vs proximal CTEPH). | ||||
†p<0.001 (IPAH vs proximal CTEPH); p = 0.008 (IPAH vs distal CTEPH). | ||||
‡p<0.001 (IPAH vs proximal CTEPH); p = 0.001 (IPAH vs distal CTEPH). | ||||
§p = 0.007 (distal CTEPH vs proximal CTEPH). | ||||
¶p = 0.01 (IPAH vs proximal CTEPH); p = 0.006 (proximal CTEPH vs distal CTEPH). | ||||
**p = 0.002 (IPAH vs proximal CTEPH). | ||||
Haemodynamics | ||||
RAP | 9.5 (6) | 10.2 (7.9) | 8.6 (5.8) | 0.45 |
Cardiac index | 1.91 (0.68) | 2.11 (0.68) | 2.07 (0.67) | 0.23 |
mPAP† | 54.8 (13.1) | 47.3 (11.9) | 45.4 (12.0) | <0.001 |
TPR‡ | 18.1 (8.3) | 12.9 (5.2) | 12.4 (5.2) | <0.001 |
Pulmonary function | ||||
FEV1 (% predicted) | 84.0 (16) | 74.7 (22.1) | 80.4 (18.5) | 0.07 |
FVC (% predicted)§ | 92.0 (16.8) | 83.3 (24.7) | 95.7 (16.9) | 0.009 |
TLC (% predicted) | 98.2 (15.2) | 90.8 (19.8) | 95.6 (15.5) | 0.09 |
Tlco (% predicted)¶ | 66.3 (19.3) | 62.8 (13.4) | 75.5 (17.7) | 0.002 |
Kco (% predicted)** | 78.8 (22.1) | 85.3 (17.4) | 91.6 (19.3) | 0.002 |