Table 1

 Baseline characteristics of the IPAH, distal CTEPH and proximal CTEPH groups

IPAH(n = 96)Distal CTEPH(n = 35)Proximal CTEPH(n = 68)p Value
BMI, body mass index; BMPR2, bone morphogenetic protein receptor type II; CTEPH, chronic thromboembolic pulmonary hypertension; DVT, deep vein thrombosis; IPAH, idiopathic pulmonary arterial hypertension; 6MWD, 6 min walking distance; TED, thromboembolic event.
Significant pairwise comparisons are listed below:
*p = 0.005 (IPAH vs proximal CTEPH); p = 0.002 (IPAH vs distal CTEPH).
†p<0.001 (IPAH vs proximal CTEPH); p = 0.04 (proximal CTEPH vs distal CTEPH).
‡p = 0.046 (IPAH vs proximal CTEPH); p = 0.046 (IPAH vs distal CTEPH).
§p<0.001 (IPAH vs proximal CTEPH); p<0.001 (IPAH vs distal CTEPH).
¶p<0.001 (IPAH vs proximal CTEPH); p<0.001 (IPAH vs distal CTEPH).
**p = 0.026 (proximal vs distal CTEPH).
Mean (SD) age (years)*46.2 (16.9)55.9 (13.1)54.8 (14.6)<0.001
Male sex†29%43%69%<0.001
Mean (SD) BMI (kg/m2)27.1 (5.8)27.9 (7.5)27.4 (3.9)0.77
Positive BMPR2 status‡15% (n = 40)0% (n = 25)0% (n = 25)0.018
Prior TED§5.2%74.3%75%<0.001
Prior DVT¶3.1%28.6%30.9%<0.001
Previous splenectomy**3.1%11.4%1.6%0.042
Positive smoking history47.9%65.7%50%0.18
WHO functional class
    II20 (21%)10 (29%)11 (16%)
    III50 (53%)17 (49%)32 (47%)
    IV24 (26%)8 (22%)25 (37%)0.37
Mean (SD) 6MWD (m)257 (118)254 (99)256 (131)1.00