Effect of peptide inhalation on the concentrations of mast cell- and basophil-associated pharmacological mediators in bronchoalveolar lavage (BAL) fluid from responders and non-responders
| Mediators | Responders (R) | Non-responders (NR) | p Value(R vs NR) | ||||
|---|---|---|---|---|---|---|---|
| Diluent | Peptide | p Value | Diluent | Peptide | p Value | ||
| LT, leukotriene; PG, prostaglandin. | |||||||
| Values are expressed as median (range). | |||||||
| Statistical comparisons of diluent and peptide inhalation (within-group comparisons) were performed using two-tailed Wilcoxon signed tank tests. Between-group comparisons of the change from diluent to peptide in responders and non-responders were performed using the non-parametric Mann-Whitney test. | |||||||
| All values are expressed as pg/ml of BAL fluid with the exception of histamine, C3a and tryptase (ng/ml) and basogranulin (mU/ml). | |||||||
| *C5a was not detected in any sample. | |||||||
| Histamine | 4.8 (2.0–9.9) | 7.9 (2.7–17.3) | 0.02 | 3.8 (0.7–8.1) | 5.5 (1.7–8.7) | 0.18 | 0.24 |
| Tryptase | 0.6 (0–2.3) | 0.6 (0–6.3) | 0.76 | 0 (0–0.6) | 0.2 (0–1.5) | 0.08 | 0.98 |
| Basogranulin | 39.9 (0–995.0) | 49.3 (2.7–160.1) | 0.52 | 47.0 (8.2–194.4) | 29.3 (3.2–117.0) | 0.06 | 0.13 |
| C3a* | 5.4 (4.0–8.7) | 5.9 (3.2–9.0) | 0.76 | 8.8 (5.4–11.1) | 7.5 (4.6–9.3) | 0.31 | 0.21 |
| LTC4/D4 | 5.5 (2.2–17.7) | 8.2 (1.4–19.5) | 0.73 | 3.2 (1.1–12.1) | 3.7 (1.2–26.0) | 0.09 | 0.51 |
| LTE4 | 6.0 (1.2–34.6) | 6.7 (2.5–27.8) | 0.38 | 7.0 (2.3–14.1) | 5.8 (2.7–25.6) | 0.79 | 0.62 |
| PGD2 | 0.95 (0–8.2) | 2.7 (0–9.8) | 0.92 | 0.9 (0–9.5) | 2.9 (0–21.2) | 0.09 | 0.16 |
| PGF2α | 2.1 (0.7–3.4) | 1.6 (0.6–4.6) | 0.73 | 1.4 (0.6–4.0) | 1.4 (0.49–4.1) | 0.97 | 0.93 |