Table 3

 Effect of peptide inhalation on the concentrations of mast cell- and basophil-associated pharmacological mediators in bronchoalveolar lavage (BAL) fluid from responders and non-responders

MediatorsResponders (R)Non-responders (NR)p Value(R vs NR)
DiluentPeptidep ValueDiluentPeptidep Value
LT, leukotriene; PG, prostaglandin.
Values are expressed as median (range).
Statistical comparisons of diluent and peptide inhalation (within-group comparisons) were performed using two-tailed Wilcoxon signed tank tests. Between-group comparisons of the change from diluent to peptide in responders and non-responders were performed using the non-parametric Mann-Whitney test.
All values are expressed as pg/ml of BAL fluid with the exception of histamine, C3a and tryptase (ng/ml) and basogranulin (mU/ml).
*C5a was not detected in any sample.
Histamine4.8 (2.0–9.9)7.9 (2.7–17.3)0.023.8 (0.7–8.1)5.5 (1.7–8.7)0.180.24
Tryptase0.6 (0–2.3)0.6 (0–6.3)0.760 (0–0.6)0.2 (0–1.5)0.080.98
Basogranulin39.9 (0–995.0)49.3 (2.7–160.1)0.5247.0 (8.2–194.4)29.3 (3.2–117.0)0.060.13
C3a*5.4 (4.0–8.7)5.9 (3.2–9.0)0.768.8 (5.4–11.1)7.5 (4.6–9.3)0.310.21
LTC4/D45.5 (2.2–17.7)8.2 (1.4–19.5)0.733.2 (1.1–12.1)3.7 (1.2–26.0)0.090.51
LTE46.0 (1.2–34.6)6.7 (2.5–27.8)0.387.0 (2.3–14.1)5.8 (2.7–25.6)0.790.62
PGD20.95 (0–8.2)2.7 (0–9.8)0.920.9 (0–9.5)2.9 (0–21.2)0.090.16
PGF2.1 (0.7–3.4)1.6 (0.6–4.6)0.731.4 (0.6–4.0)1.4 (0.49–4.1)0.970.93