Univariable and multivariable models for predicting severe airflow obstruction in the overall cohort, index subject and non-index subjects
| All OR(95% CI) | Index OR(95% CI) | Non-index OR(95% CI) | |
|---|---|---|---|
| *Univariate model includes sex (male = 1, female = 0), pack-years of cigarettes, ever-smoking (yes = 1, no = 0), asthma (yes = 1, no = 0), pneumonia (yes = 1, no = 0), chronic bronchitis (yes = 1, no = 0), index case (yes = 1, no = 0). | |||
| †Multivariate model includes sex (male = 1, female = 0), pack-years of cigarettes, ever-smoking (yes = 1, no = 0), asthma (yes = 1, no = 0), pneumonia (yes = 1, no = 0), chronic bronchitis (yes = 1, no = 0), index case (yes = 1, no = 0). | |||
| ‡Estimate for pack-years is for each pack-year smoked. | |||
| Number with severe airflow obstruction | 158/377 (42%) | 90/140 (64%) | 68/237 (27%) |
| Univariable predictors* | |||
| Age | 1.01 (0.99 to 1.03) | 1.07 (0.97 to 1.05) | 1.01 (0.98 to 1.04) |
| Sex | 3.14 (2.05 to 4.80) | 2.43 (1.18 to 4.97) | 4.59 (2.49 to 8.46) |
| Pack-years of cigarettes‡ | 1.09 (1.06 to 1.11) | 1.09 (1.05 to 1.13) | 1.08 (1.05 to 1.10) |
| Ever smoking status | 6.89 (4.14 to 11.47) | 5.54 (2.43 to 12.62) | 6.44 (3.47 to 12.90) |
| History of asthma | 3.14 (2.03 to 4.85) | 2.43 (1.18 to 5.01) | 3.33 (1.78 to 5.84) |
| History of pneumonia | 3.57 (2.28 to 5.58) | 3.50 (1.66 to 7.37) | 3.16 (1.71 to 5.81) |
| Chronic bronchitis | 2.98 (1.80 to 4.93) | 2.02 (0.83 to 4.90) | 4.18 (2.17 to 8.05) |
| Index case | 4.47 (2.86 to 6.99) | – | – |
| Multivariable predictors† | |||
| Sex | 4.05 (2.63 to 7.45) | 2.64 (1.05 to 6.53) | 5.51 (2.57 to 11.81) |
| Pack-years of cigarettes‡ | 1.06 (1.03 to 1.09) | 1.10 (1.04 to 1.16) | 1.04 (1.00 to 1.08) |
| Ever smoking status | 2.75 (1.27 to 5.97) | 1.51 (0.42 to 5.43) | 3.66 (1.36 to 9.87) |
| History of asthma | 3.24 (1.81 to 5.81) | 3.70 (1.45 to 9.44) | 3.18 (1.47 to 6.89) |
| History of pneumonia | 4.09 (2.25 to 7.45) | 4.71 (1.80 to 12.33) | 3.89 (1.78 to 8.50) |
| Chronic bronchitis | 2.63 (1.37 to 5.07) | 2.77 (0.90 to 8.47) | 2.78 (1.22 to 6.35) |
| Index case | 3.53 (1.99 to 6.24) | – | – |