General demographic data of the 378 PI ZZ individuals*
| Demographic characteristics | All(N = 378) | Index(N = 140) | Non-index(N = 238) | p Value Index vs non-index |
|---|---|---|---|---|
| FEV1, forced expiratory volume in 1 s. | ||||
| *Includes 372 siblings, 2 parents, 1 uncle, 3 children of siblings. | ||||
| †Post-bronchodilator. | ||||
| Sex (female) | 205 (54%) | 73 (52%) | 132 (55%) | 0.53 |
| Mean (SD) age (years) | 52.2 (9.7) | 52.9 (9.5) | 51.7 (9.8) | 0.25 |
| Mean (SD) FEV1% predicted† | 65.9 (33.5) | 49.0 (28.5) | 72.3 (32.7) | <0.0001 |
| Mean (SD) FEV1/FVC ×100† | 55.1 (20.7) | 43.9 (17.3) | 61.4 (19.8) | <0.0001 |
| Smoking status | ||||
| Ever smoker | 233 (62%) | 105 (75%) | 128 (54%) | <0.0001 |
| Current smoker | 13 (3%) | 1 (<1%) | 12 (5%) | 0.03 |
| Median (IQR) pack-years for smokers | 16 (7–24) | 17 (9–25) | 15 (6–22) | 0.02 |
| Median (IQR) age at onset of smoking (years) | 17 (15–19) | 17 (15–19) | 17 (15–19) | 0.70 |
| Lung trouble before age 16 | 93 (25%) | 41 (29%) | 52 (22%) | 0.11 |
| History of wheezing | 244(65%) | 102 (73%) | 142 (60%) | 0.01 |
| Doctor confirmed asthma | 139 (37%) | 64 (46%) | 75 (32%) | 0.006 |
| Asthma before age 16 | 20 (5%) | 13 (9%) | 7 (3%) | 0.008 |
| History of pneumonia | 220 (58%) | 95 (68%) | 125 (53%) | 0.004 |
| Pneumonia before age 16 | 47 (12%) | 17 (12%) | 30 (13%) | 0.90 |
| Chronic bronchitis | 83 (22%) | 33 (24%) | 50 (21%) | 0.56 |