Effect of C-reactive protein (CRP, mg/l) on change in lung function using linear regression between 1991 and 2000
| 1991 Serum CRP(n = 1241) | Average serum CRP (mean of 1991 and 2000)(n = 1219) | |
|---|---|---|
| FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; BMI, body mass index. | ||
| Residuals calculated for men and women individually and adjusted for gender, age, age2, height and age-height interaction and the model was adjusted for smoking status (categorical), smoking pack-years, and BMI (continuous). | ||
| *n = 1240. | ||
| †n = 1218. | ||
| Decline in FEV1 (ml) | 0 (–3 to +4) | –2 (–7 to +3) |
| Stratified by smoking status | ||
| Never | +1 (–2 to +4) | 0 (–6 to +4) |
| Ex | –2 (–15 to +10) | –5 (–18 to +8) |
| Current | +2 (–16 to +21) | –3 (–20 to +14) |
| pinteraction = 0.969 | pinteraction = 0.978 | |
| Stratified by gender | ||
| Male | + 3 (–3 to +9) | 0 (–8 to +9) |
| Female | –2 (–5 to +2) | –5 (–10 to 0) |
| pinteraction = 0.082 | pinteraction = 0.116 | |
| Stratified by BMI(kg/m2) | ||
| >20 | +27 (–30 to +84) | +53 (+8 to +99) |
| 20–24.9 | +3 (–5 to +11) | –4 (–14 to +6) |
| 25–29.9 | +3 (–3 to +9) | +1 (–7 to +9) |
| >30 | –2 (–7 to +3) | –4 (–12 to +5) |
| pinteraction = 0.563 | pinteraction = 0.685 | |
| FVC (ml) | +3 (–1 to +7)* | +1 (–6 to +7)† |
| Stratified by smoking status | ||
| Never | +4 (–1 to +8) | +4 (–3 to +10) |
| Ex | –3 (–20 to +13) | –10 (–26 to +7) |
| Current | +16 (–7 to +39) | +9 (–12 to +30) |
| pinteraction = 0.489 | pinteraction = 0.471 | |
| Stratified by gender | ||
| Male | +8 (0 to +16) | +7 (–4 to +18) |
| Female | –1 (–5 to +3) | –5 (–12 to +2) |
| pinteraction = 0.016 | pinteraction = 0.027 | |
| Stratified by BMI(kg/m2) | ||
| >20 | –22 (–104 to +60) | +41 (–29 to +111) |
| 20–24.9 | +5 (–5 to +15) | +1 (–11 to +14) |
| 25–29.9 | +9 (+1 to +16) | +5 (–5 to +16) |
| >30 | –1 (–7 to +5) | –4 (–14 to +6) |
| pinteraction = 0.0148 | pinteraction = 0.0618 | |