TUNEL analysis of apoptosis induced in malignant mesothelioma (MMe) cells by single drugs or by drug combinations
| Treatment | MMP | REN | ISTMES2 |
|---|---|---|---|
| Data are expressed as the mean (SE) percentage of biotin-dU positive nuclei for 100 counted cells at a magnification of 100×. The values for each treatment were subtracted from untreated control values. Different concentrations of drugs were used, as described in the Methods section. | |||
| *p⩽0.001, difference between theoretical additive effects of chemotherapeutics (gemcitabine or pemetrexed) + imatinib vs measured effects of imatinib/chemotherapeutic combinations. | |||
| Imatinib | 1.10 (0.35) | 1.00 (0.23) | 1.70 (0.19) |
| Gemcitabine | 1.58 (0.42) | 3.07 (0.51) | 2.80 (0.32) |
| Pemetrexed | 0.98 (0.47) | 1.04 (0.26) | 1.00 (0.26) |
| Imatinib + gemcitabine | 5.34 (0.40)* | 9.72 (0.48)* | 1.02 (0.48)* |
| Imatinib + pemetrexed | 8.48 (0.40)* | 4.72 (0.26)* | 0.04 (0.26)* |