Table 2

 Change in variables between visits for all patients

Visit 2–visit 1(n = 37)Visit 3–visit 1(n = 36)
ADLs, activities of daily living; FEV1, forced expiratory volume in 1 s; %FL, percentage flow limitation; IC, inspiratory capacity; LCADL, London Chest Activities of Daily Living; OCD, oxygen cost diagram; PEF, peak expiratory flow; PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial partial pressure of oxygen; Rrs, resistance of the respiratory system; SGRQ, St George’s Respiratory Questionnaire; TDI, Transitional Dyspnoea Index; VAS, visual analogue scale; VC, vital capacity; Xrs, reactance of the respiratory system.
All data are mean (SEM) unless otherwise indicated.
The statistical significance of paired changes was assessed using the Student’s paired t test. The statistical significance of percentage changes was assessed using the equivalent one sample test, with the null hypothesis being a mean change of zero.
*p<0.1, †p<0.05, ‡p<0.005, §p<0.001.
Spirometry
    VC
        Litre0.297 (0.061)§0.354 (0.071)§
        % predicted10.3 (1.8)§12.1 (2.3)§
    FEV1
        Litre0.153 (0.046)‡0.274 (0.064)§
        % predicted6.4 (1.7)‡11.4 (2.3)§
    FEV1/VC (%)0.2 (1.1)3.18 (1.47)†
    PEF
        l/s0.455 (0.140)‡0.696 (0.142)§
        % predicted6.8 (2.2)‡11.0 (2.2)§
    IC
        Litre0.241 (0.054)§0.295 (0.056)§
        % predicted9.87 (1.98)§11.9 (2.3)§
Capillary earlobe blood gases
    PaO2 (kPa)0.85 (0.18)§1.18 (0.21)§
    PaCO2 (kPa)0.06 (0.13)0.02 (0.14)
Breathing pattern
    Respiratory rate (/min)−1.37 (0.65)†−1.57 (0.64)†
    Tidal volume (l)−0.002 (0.029)0.008 (0.183)
Oscillometry
    Rrs
        Kpa· s/l−0.025 (0.02)−0.009 (0.024)
        %−3.60 (3.47)−0.95 (3.90)
    Xrs
        KPa· s/l0.132 (0.034)§0.143 (0.039)‡
        %27.9 (7.0)§35.2 (8.9)§
    Rrs,insp.
        KPa· s/l−0.025 (0.015)−0.024 (0.019)
        %−4.97 (3.25)−3.90 (3.9)
    Xrs,insp.
        KPa· s/l0.032 (0.011)†0.073 (0.017)§
        %13.0 (4.5)†27.4 (6.7)§
    Rrs,exp
        KPa· s/l−0.02 (0.027)0.006 (0.03)
        %−2.57 (4.09)1.25 (4.22)
    Xrs,exp
        KPa· s/l0.19 (0.05)§0.18 (0.05)‡
        %31.5 (7.8)§37.1 (10.0)‡
    %FL (%)−19.2 (6.1)‡−19.5 (7)†
Symptom score
    VAS
        Sleep30.5 (8.1)‡23.5 (9.3)†
        Wheeze17.7 (6.5)†22.6 (8.4)†
        Mobility31.8 (6.5)§37.1 (7.6)§
    Paggiaro−1.70 (0.54)‡−3.14 (0.62)§
Dyspnoea
    VAS16.9 (4.3)§27.0 (5.7)§
    TDI1.92 (0.33)§3.39 (0.405)§
    OCD0.068 (0.018)‡0.101 (0.027)‡
    Borg−0.973 (0.205)§−1.15 (0.281)‡
Impairment of activities of daily living (LCADL)−7.2 (0.9)§−11.6 (1.3)§
SGRQ
    Symptoms0.12 (2.41)
    Activities−4.76 (2.26)†
    Impacts−9.88 (2.92)‡
    Total−6.67 (1.96)‡