Baseline values from visit 1
| Baseline values | |
|---|---|
| ADLs, activities of daily living; BDI, Baseline Dyspnoea Index; BMI, body mass index; FEV1, forced expiratory volume in 1 s; %FL, percentage flow limitation; IC, inspiratory capacity; LCADL, London Chest Activities of Daily Living; OCD, oxygen cost diagram; PaCO2, arterial partial pressure of carbon dioxide; PEF, peak expiratory flow; PaO2, arterial partial pressure of oxygen; Rrs, resistance of the respiratory system; SGRQ, St George’s Respiratory Questionnaire; TDI, Transitional Dyspnoea Index; VAS, visual analogue scale; VC, vital capacity; Xrs, reactance of the respiratory system. | |
| All data are mean (SD) unless otherwise indicated. | |
| *Median (range). | |
| Number (n, male) | 39 (16) |
| Age (years) | 63.1 (6.9) |
| Number with BMI <25:25–30:>30 | 19:13:7 |
| Smoking history | |
| Ex or current smokers:lifelong non-smokers | 39:0 |
| Pack-years | 40 (10–100)* |
| Time interval (days) | |
| Admission–visit 1 | 2 (0–3)* |
| Visit 1–visit 2 | 7 (3–15)* |
| Visit 1–visit 3 | 42 (35–102)* |
| Spirometry | |
| VC | |
| Litre | 2.45 (0.90) |
| % predicted | 88 (25) |
| FEV1 | |
| Litre | 0.96 (0.42) |
| % predicted | 43 (16) |
| FEV1/VC (%) | 40 (10) |
| PEF | |
| l/s | 2.75 (1.11) |
| % predicted | 43 (16) |
| IC | |
| Litre | 1.70 (0.65) |
| % predicted | 77 (28) |
| Capillary earlobe blood gases | |
| PaO2 (kPa) | 8.07 (1.35) |
| PaCO2 (kPa) | 4.74 (0.77) |
| Breathing pattern | |
| Respiratory rate (/min) | 19.3 (5.6) |
| Tidal volume (l) | 0.737 (0.249) |
| Oscillometry | |
| Rrs (kPa. s/l) | 0.605 (0.194) |
| Xrs (kPa. s/l) | −0.594 (0.269) |
| Rrs,insp (kPa. s/l) | 0.517 (0.152) |
| Xrs,insp (kPa. s/l) | −0.298 (0.117) |
| Rrs,exp (kPa. s/l) | 0.658 (0.231) |
| Xrs,exp (kPa. s/l) | −0.776 (0.389) |
| %FL (%) | 68 (35) |
| Symptom score | |
| VAS | |
| Sleep | −37.6 (42.7) |
| Wheeze | −39.4 (36.0) |
| Mobility | −65.8 (34.5) |
| Paggiaro | 9.18 (2.73) |
| Dyspnoea | |
| VAS | 39.7 (25.9) |
| BDI | 3.79 (2.58) |
| TDI | −5.41 (1.55) |
| OCD | 0.280 (0.088) |
| Borg | 3.62 (1.54) |
| Impairment of activities of daily living (LCADL) | 54.1 (5.8) |
| Health-related quality of life (SGRQ) | |
| Symptoms | 83.1 (13.9) |
| Activities | 87.9 (11.9) |
| Impacts | 62.8 (16.2) |
| Total | 73.8 (12.5) |