Table 1 Collected data from studies dealing with vastus lateralis fibre typing in COPD
ReferenceN (M/F)Age (y)BMI(kg/m2)FEV1(%pred)FVC(%pred)FEV1/FVC (%)Tlco (%pred)Pao2 (kPa)Type I (%)Type IIA (%)Type IIX (%)Fibre typing
1314 (14/0)66 (6)*28 (4)*31 (9)†64 (12)*43 (10)*60 (26)*9.1 (0.8)*30 (11)*IHC
146 (?/?)64 (9)26 (4)32 (11)71 (11)34 (8)11.7 (1.0)21 (12)¶42 (7)¶39 (3)¶HC
1519 (16/3)65 (8)*26 (4)*42 (13)*79 (8)*43 (16)*49 (10)*8.9 (0.7)*38 (15)*48 (19)*13 (8)*HC
1622 (22/0)65 (9)51 (12)79 (17)‡50 (?)‡§77 (27)10.8 (1.1)36 (17)40 (13)23 (22)SDS PAGE
1015 (12/3)67 (9)24 (4)42 (14)83 (15)†40 (12)†63 (24)9.9 (1.2)19 (14)35 (12)46 (19)HC
1713 (6/7)61 (12)23 (1)37 (12)75 (11)36 (10)†47 (24)9.0 (1.2)25 (7)47 (11)28 (10)SDS PAGE
1818 (18/0)70 (6)*26 (3)*35 (12)*58 (12)*41 (9)*32 (17)*39 (12)30 (11)HC
198 (8/0)61 (5)24 (?)§42 (6)71 (14)‡70 (14)44 (15)HC
2017 (17/0)69 (5)25 (3)34 (12)58 (14)†38 (7)†30 (14)56 (15)15 (14)SDS PAGE
2117 (15/2)66 (8)26 (4)38 (12)59 (16)66 (29)10.4 (1.6)31 (16)26 (15)††27 (29)HC‡‡
2216 (?/?)67 (4)24 (4)39 (16)63 (14)39 (9)10.4 (1.2)26 (12)¶20 (16)¶HC
2329 (20/9)65 (5)25 (5)37 (16)59 (16)43 (11)56 (32)10.4 (1.6)27 (12)¶32 (16)¶22 (16)¶HC‡‡
2415 (15/0)67 (8)25 (4)46 (16)64 (16)48 (12)71 (20)10.9 (1.7)40 (8)35 (4)25 (3)IHC
2532 (32/0)64 (8)*28 (5)*42 (14)*46 (9)*78 (21)*11.3 (1.8)*35 (12)*42 (13)*22 (11)*HC
269 (?/?)66 (10)26 (?)§8.5 (2.0)29 (12)35 (12)31 (15)HC‡‡
2712 (12/0)65 (5)25 (3)31 (9)59 (16)35 (?)§72 (22)10.8 (1.1)27 (17)51 (15)22 (16)SDS PAGE
2818 (13/5)63 (7)*23 (?)*§29 (?)*§67 (?)*‡§34 (?)*‡§9.2 (0.9)*20 (11)*HC
2920 (17/3)65 (8)26 (?)§37 (11)61 (16)40 (?)§63 (18)10.7 (1.7)34 (14)51 (15)††15 (12)HC
829 (17/12)†63 (10)22 (5)39 (12)69 (15)45 (10)8.8 (1.2)†36 (11)40 (9)24 (10)HC
Abstracts
3014 (10/4)†61 (9)†24 (4)†38 (11)†46 (13)†45 (26)†38 (14)†18 (8)45 (11)IHC
31/32**47 (47/0)67 (8)* **24 (?)*§**40 (12)* **41 (11)*‡**48 (22)*§**9.2 (1.8)* **42 (8)*†¶††27 (5)*†¶††29 (7)*†¶††HC
33/34**29 (29/0)66 (6)**24 (3)**42 (13)**66 (17)**62 (18)†**9.1 (1.0)**39 (22)†¶36 (17)†¶29 (16)†¶HC
  • N, study group size; BMI, body mass index; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; Tlco, carbon monoxide transfer factor; HC, histochemistry; IHC, immunohistochemistry; SDS PAGE, gel electrophoresis analysis of myosin heavy chain isoforms; ? indicates that the data were not given or could not be calculated.

  • *Calculated from combined subgroups.

  • †Additional data obtained from authors through personal communication, used with permission.

  • ‡Vital capacity instead of forced vital capacity.

  • §Calculated from average data as presented in the paper.

  • ¶Not all subjects had a muscle biopsy.

  • **Data obtained from a related publication.

  • ††Determined in a figure.

  • ‡‡Sum of fibre type proportions is not 100% because (small) proportions of hybrid fibres were excluded from analysis.