Table 2 Inflammatory markers in sputum and blood at baseline of patients in the efficacy analysis
%×105 cells/g sputumConcentration
Induced sputum
    Total non-squamous cells18.0 (2.0–87.1)†
    Squamous cells10.7 (0–74.4)
    Neutrophils74.4 (46.4–95.4)13.0 (1.7–84)†
    Macrophages20.5 (2.6–47.6)3.2 (0.2–21.1)†
    Eosinophils0.8 (0.02–8.0)†0.14 (0.001–4.2)†
    Lymphocytes1.4 (0–4.6)0.24 (0.024–1.87)†
Markers in sputum supernatant
    IL-8 (ng/ml)12.5 (0.49–179.9)†
    Neutrophil elastase (μg/ml)3.61 (0.14–120.3)†
    Lactoferrin (μg/ml)73.5 (0.8–512.9)†
    ECP (μg/l)170.8 (15.6–5767.5)†
    α2-macroglobulin (ng/ml)1345.7 (20.1–15063.04)†
Blood
    E-selectin (ng/ml)51.7 (33.5–94.6)†
    TNFα (ng/ml)8.1 (1.6–37.0)†
  • IL, interleukin; ECP, eosinophil cationic protein; TNFα, tumour necrosis factor α.

  • Data are median or †geometric mean (minimum − maximum).