Phenotype* | Subjects | Covariates | Chromosome | cM | LOD | p Value |
---|---|---|---|---|---|---|
The maximum LOD score for each analysis is reported. Full results are available in supplementary table 3. | ||||||
*Definitions of BDR phenotypes7: | ||||||
BDRbase = (FEV1post-bronchodilator-FEV1pre-bronchodilator)/FEV1pre-bronchodilator ×100%. | ||||||
BDRpred = (FEV1post-bronchodilator-FEV1pre-bronchodilator)/FEV1predicted ×100%. | ||||||
BDRabs = (FEV1post-bronchodilator-FEV1pre-bronchodilator). | ||||||
All three BDR variables were log10 transformed for analysis. | ||||||
BDRbase | All | None | 4 | 70 | 1.26 | 0.008 |
Non-smokers | None | 10 | 31 | 1.59 | 0.002 | |
Smokers | Gender | 16 | 66 | 1.31 | 0.019 | |
BDRpred | All | None | 9 | 49 | 1.25 | 0.007 |
Non-smokers | None | 10 | 31 | 1.69 | 0.002 | |
Smokers | Gender | 16 | 66 | 1.22 | 0.018 | |
BDRabs | All | None | 9 | 49 | 1.53 | 0.003 |
Non-smokers | None | 9 | 49 | 1.72 | <0.001 | |
Smokers | Gender | 16 | 66 | 1.60 | 0.012 |