Table 2

Genome-wide linkage analysis for FEV₁ and FEV₁/FVC in all subjects, non-smokers and smokers only

Phenotype	Bronchodilator	Subjects	Covariates	Chromosome	cM	LOD	p Value
FEV₁, forced expiratory volume in one second; FVC, forced vital capacity; ht, height; smoker, ever smoker; packs, pack-years; wt, weight.
Age², ht² and wt² represent the quadratic terms for age, height and weight, respectively.
The maximum LOD score for each analysis is reported. Full results are available in supplementary tables 1 and 2.
FEV₁	Pre	All	Age, age², ht, ht², wt², gender, smoker	6	127	1.63	0.004
		Non-smokers	Age, age², ht, ht², wt², gender	9	153	1.09	0.014
		Smokers	Age, age², ht, gender	3	241	2.74	<0.001
	Post	All	Age, age², ht, ht², wt², gender	7	150	2.13	0.002
		Non-smokers	Age, age², ht, ht², wt², gender	7	150	1.73	0.003
		Smokers	Age, age², ht, gender	4	138	2.66	<0.001
FEV₁/FVC	Pre	All	Age	2	245	1.53	0.004
		Non-smokers	Age, ht	4	95	1.50	0.004
		Smokers	Age, age²	9	72	1.52	0.002
	Post	All	Age, age², ht, wt	7	74	1.40	0.007
		Non-smokers	Age, ht, wt	18	117	1.46	0.006
		Smokers	Age, age², packs	5	49	3.27	<0.001