Clinical characteristics of subjects with neutrophilic, eosinophilic and paucigranulocytic asthma, bronchiectasis and controls
| Neutrophilic asthma | Eosinophilic asthma | Paucigranulocytic asthma | Bronchiectasis | Controls | p Value* | |
|---|---|---|---|---|---|---|
| FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; ICS, inhaled corticosteroid; IQR, interquartile range; –, data not collected. | ||||||
| *Kruskal–Wallis or one-way analysis of variance (age, FEV1% predicted, FEV1/FVC) p value for five group analysis. | ||||||
| †Bonferroni-corrected p<0.05 versus neutrophilic asthma. | ||||||
| ‡Bonferroni-corrected p<0.05 versus asthma and bronchiectasis. | ||||||
| §Dose–response slope (% fall FEV1/ml 4.5% saline), healthy n = 12, neutrophilic asthma n = 4, eosinophilic asthma n = 20, paucigranulocytic asthma n = 10, bronchiectasis n = 4. | ||||||
| ¶p<0.0025 Kruskal–Wallis versus eosinophilic and paucigranulocytic asthma. | ||||||
| **ICS dose calculated as 1 μg of beclomethasone = 1 μg budesonide = 0.5 μg fluticasone. | ||||||
| Number | 7 | 26 | 16 | 9 | 13 | |
| Mean (range) age, years | 64 (40–72) | 54 (24–70) | 56 (22–80) | 56 (21–72) | 41 (21–67)† | 0.021 |
| Sex, male/female | 2/5 | 7/19 | 5/11 | 2/7 | 4/9 | 1 |
| Atopy, n (%) | 7 (100) | 21 (81) | 11 (69) | 6 (67) | 7 (54) | 0.182 |
| Ex smoker, n (%) | 4 (57) | 8 (31) | 6 (38) | 2 (22) | 1(8) | 0.176 |
| Mean (range) pack-years | 34 (22–42) | 42 (32–86) | 14.5 (0.5–22) | 6.4 (5.7–7) | 0.5 | 0.105 |
| Mean (SD) FEV1% predicted, post-bronchodilator | 65 (26) | 83 (19) | 81 (25) | 73 (21) | 107 (13)‡ | <0.001 |
| Mean (SD) FEV1/FVC, % | 62 (13) | 69 (10) | 68 (12) | 66 (7) | 84 (5)‡ | <0.001 |
| Median (IQR) dose–response slope§ | 5.1 (0.8–13.9) | 3.5 (1.2–12.1) | 2.9 (1.3–8.6) | 0.9 (0.5–1.2) | 0.4 (0.2–0.6)¶ | <0.001 |
| Mean (range) duration of asthma, years | 38 (14–71) | 22 (0.5–57) | 33 (3–61) | — | — | |
| Median (IQR) ICS dose, μg** | 1600 (500–2000) | 2000 (1000–2000) | 1800 (1000–2000) | 1300 (800–2000) | — | |
| Culture positive, n (%) | 3 (43) | 2 (8) | 0 (0) | 5 (56) | — | <0.001 |