Table 2

 Ratio of stained growth factor to vessel numbers in airway biopsy specimens before and after treatment with ICS or placebo

Mean vessel staining (pre-ICS)Mean vessel staining (post-ICS)Significance of ICS treatment change vs placebo
ICS (%)Placebo (%)ICS (%)Placebo (%)
ICS, inhaled corticosteroid; VEGF, vascular endothelial growth factor; VEGFR1, VEGFR2, vascular endothelial growth factor receptors 1 and 2; An1, angiopoietin-1.
VEGF staining at baseline was normalised to 100% and receptor staining is given as a percentage of the respective vessels counted.
VEGF100 (12)100 (17)75 (9)85 (13)NS
VEGFR165 (8)70 (11)100 (10)86 (9)NS
VEGFR242 (9)55 (13)100 (14)67 (8)NS (p = 0.09)
Ang168 (3)74 (7)100 (5)72 (8)NS (p = 0.07)