Table 4 Association between EPHX1 phenotypes and asthma stratified by GSTP1 Ile105Val genotype
EPHX1 metabolic phenotypes by asthma phenotypesGSTP1 Ile105Valp Value‡
N*OR† (95% CI)N*OR† (95% CI)N*OR† (95% CI)
Lifetime asthma
    High201/361.12 (0.74 to 1.70)217/491.34 (0.92 to 1.94)46/234.01 (1.97 to 8.16)0.006
Current asthma
    High201/221.15 (0.67 to 2.00)217/321.31 (0.80 to 2.13)46/144.42 (1.65 to 11.83)0.03
Early persistent asthma
    High201/80.65 (0.29 to 1.43)217/191.55 (0.87 to 2.76)46/103.89 (1.32 to 11.43)0.02
Late onset asthma
    High201/261.65 (0.99 to 2.75)217/241.28 (0.78 to 2.11)46/104.40 (1.56 to 12.45)0.06
  • *Frequencies represent children with no asthma/children with asthma phenotype under study. Children with missing data on GSTP1 Ile105Val were excluded.

  • †ORs represent odds ratios for asthma outcomes associated with high EPHX1 phenotype within each stratum of GSTP1 Ile105Val genotype and were adjusted for age, sex, race/ethnicity, in utero exposure to maternal smoking, number of smokers at home, community of residence, parental education, health insurance and parental history of asthma.

  • ‡p values for the EPHX1 activity phenotype by GSTP1 Ile105Val genotype interactions were obtained from likelihood ratio tests from a non-stratified model with appropriate interaction terms and were based on 2df.