Table 4 Numbers with work-related respiratory disease according to case definitions for extrinsic allergic alveolitis (EAA), occupational asthma and humidifier fever with year of onset of symptoms from phase III
DiseaseMet case definition
Symptoms before 2003Symptoms 2003 and onwardsTotal
Occupational asthma373774
Humidifier fever167
EAA meeting at least 4 out of 7 Fox criteria31619
Numbers meeting each of the Fox criteria for EAA16
(1) Physician diagnosis of EAA (probable or definite) (n = 19)31619
(2) Onset of at least 2 pulmonary symptoms (cough, wheeze, chest tightness, shortness of breath) and one systemic symptom (fever, weight loss) (n = 19)31417
(3) A history of symptoms improving regularly on days away from work and deteriorating on return to work (n = 19)31619
(4) Restrictive pattern on spirometry: FVC <80% predicted and FEV1/FVC >70% (n = 19)134
(5) Pulmonary transfer factor <80% predicted (n = 19)21214
(6) Chest radiograph or CT scan showing interstitial, reticulonodular or mosaic pattern (n = 19)21315
(7) Biopsy evidence of non-caseating granulomas and/or lymphocytosis on bronchoalveolar lavage (n = 16)189