Table 1

Published rates of decline in percentage predicted FEV₁ in cystic fibrosis

Reference	No of patients	Age (years)	Follow up (years)	Annual decline in FEV₁ % predicted
Reference	No of patients	Age (years)	Follow up (years)	Mean	SE
*Not stated.
Corey⁷	132	5–27	7	−1.87 (male)	NS*
				−2.71 (female)
Kerem⁸	39	7–40	2	−2.2	1.67
Kovesi⁹	325	4–28	15	−1.25	0.14
Konstan⁵	43	5–39	4	−3.6	0.55
Eigen¹⁰	95	6–14	4	−1.5	NS
Corey¹¹	366	18–32	15	−2.72	NS
Davis⁴	215		2–5	−2.3	0.28
Milla¹²	152		4	−2.44	NS
Merkus¹³	52	Children	3.9	−2.2	NS
Merkus¹⁴	53	Children	3.8	−1.8	NS