Table 4

 Baseline clinical characteristics of the 34 PiZ subjects studied over 3 years

Median (IQR)Median % predicted
*All lung function measurements were performed after dual bronchodilation with inhaled nebulised salbutamol (2.5 mg) and ipratropium bromide (250 μg).
FEV1, forced expiratory volume in 1 second; VC, vital capacity; RV, residual volume; TLC, total lung capacity (helium dilution); Kco, lung carbon monoxide transfer factor (mmol/min/kPa/l); UZ, upper zone scans; LZ, lower zone scans; Combined, average of upper and lower zone scans; Perc15, 15th percentile point; VI −950, voxel index at a threshold of −950 HU.
Age51 (47–56)N/A
Pack years16 (0–26)N/A
FEV1 (l)*1.2 (0.9–1.9)42
VC (l)*3.9 (3.9–4.7)100
RV (l)*2.7 (2.2–3.4)126
TLC (l)*6.9 (6.2–8.3)117
Kco*1.0 (0.8–1.3)68
UZ Perc15−942.3 (−964.9 to −926.9)N/A
UZ VI −95011.8 (6.2–23.9)N/A
LZ Perc15−969.9 (−977.6 to −943.1)N/A
LZ VI −95028.3 (11.5–34.1)N/A