Table 1

 Demographic features and lung function of study groups

Healthy controls(N = 30)Mild asthma(N = 53)Moderate asthma(N = 50)p value
*Analysis of variance.
†The mean difference is significant at the 0.05 level v healthy controls (Dunnett t test).
‡χ2 test.
§Fisher’s exact test.
¶p = 0.010 between moderate asthma and healthy controls (χ2 test).
**Mann-Whitney U test between mild and moderate asthma groups.
††Anamnestic information of prick test positivity.
Mean (SD) age (years)39 (14)43 (13)45 (12)0.075*
Sex (M:F)10:2014:3917:330.668‡
Smoking (non:current)27:348:538:120.097§
Atopy % (n)††25% (8)42% (22)54% (27)¶0.034‡
Median (IQR) inhaled corticosteroids (μg/day)500 (400–800)900 (475–1600)0.006**
Median (IQR) duration of asthma (years), range1 (0.5–1.5)0.1–393 (0.5–9)0.1–310.010**
Mean (SD) FEV13.56 (0.78)3.41 (0.82)2.7 (0.61)†<0.001*
Mean (SD) FEV1 (% predicted)97.6 (11)101 (11)80.5 (13)†<0.001*
Mean (SD) FVC4.33 (0.98)4.2 (1.03)3.57 (0.82)†0.001*
Mean (SD) FVC (% predicted)99.0 (11)103 (12)87.1 (12)†<0.001*
Mean (SD) FEV1/FVC%82.6 (5.9)81.6 (5.1)76.4 (8.1)†<0.001*
Mean (SD) FEV1/FVC (% predicted)98.1 (7.2)97.9 (7.4)92 (8.9)†<0.001*