Resting pulmonary function measured after placebo (PL) or bronchodilator (BD) but before breathing oxygen (O2) or room air (RA)
| RA + PL visit | RA + BD visit | O2 + PL visit | O2 + BD visit | p value (ANOVA) | |
|---|---|---|---|---|---|
| Values are mean (SE). | |||||
| *p<0.05 v RA+PL; †p<0.05 v RA+BD; ‡p<0.05 v O2+PL. | |||||
| FEV1, forced expired volume in 1 second; FVC, forced vital capacity; PEFR, peak expiratory flow rate; IC, inspiratory capacity; FRCpl, plethysmographic functional residual capacity; RV, residual volume; TLC, total lung capacity; sRaw, specific airway resistance; Tlco, lung carbon monoxide transfer factor; Pimax, maximal inspiratory pressure. | |||||
| FEV1 (l) | 1.17 (0.09) | 1.50 (0.13)* | 1.17 (0.09)† | 1.47 (0.13)*‡ | <0.0005 |
| FVC (l) | 2.68 (0.17) | 3.09 (0.20)* | 2.67 (0.17)† | 3.09 (0.20)*‡ | <0.0005 |
| FEV1/FVC (%) | 44 (2) | 48 (2)* | 44 (2)† | 48 (2)*‡ | <0.0005 |
| PEFR (l/s) | 3.92 (0.23) | 4.84 (0.35)* | 3.86 (0.27)† | 4.88 (0.34)*‡ | <0.0005 |
| IC (l) | 1.96 (0.13) | 2.28 (0.16)* | 1.98 (0.15)† | 2.23 (0.14)*‡ | <0.0005 |
| SVC (l) | 3.06 (0.20) | 3.45 (0.21)* | 3.11 (0.21)† | 3.41 (0.20)*‡ | <0.0005 |
| FRCpl (l) | 4.72 (0.18) | 4.31 (0.21)* | 4.80 (0.19)† | 4.34 (0.19)*‡ | <0.0005 |
| RV (l) | 3.62 (0.15) | 3.14 (0.16)* | 3.67 (0.16)† | 3.17 (0.14)*‡ | <0.0005 |
| TLC (l) | 6.68 (0.24) | 6.58 (0.27) | 6.78 (0.27) | 6.58 (0.23) | 0.055 |
| sRaw (cm H2O.s) | 22.9 (1.6) | 14.5 (1.7)* | 22.8 (1.5)† | 15.3 (1.4)*‡ | <0.0005 |
| Tlco (ml/min/mm Hg) | 16.0 (1.3) | 15.9 (1.2) | 15.9 (1.3) | 16.7 (1.2)*†‡ | 0.025 |
| Pimax (cm H2O) | 62 (4) | 61 (5) | 58 (5) | 64 (5) | 0.282 |