Table 4

 Comparisons between iPAP patients divided into groups based on the need for therapeutic lung lavage

VariablesTherapeutic lung lavagep value
Yes (N = 5)No (N = 8)
Values are given as median (range).
iPAP, idiopathic pulmonary alveolar proteinosis; LDH, lactate dehydrogenase; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; GM-CSF, granulocyte-macrophage colony-stimulating factor; BAL, bronchoalveolar lavage; anti-GM-CSF antibody, anti-granulocyte-macrophage colony stimulating factor antibodies; HRCT, high resolution computed tomography.
*Pao2 and AaPo2 were measured in the sitting position at room air.
AaPo2  =  Pao2 – Pao2; Pao2  =  (barometric pressure − 47) × Fio2 − Paco2/0.8.
LDH (IU/l)389 (265–392)243 (175–289)0.011
Pao2 (kPa)*6.5 (5.2–9.7)10.8 (8.8–11.3)0.006
AaPo2 (kPa)*7.8 (3.3–9.5)3.4 (1.5–5.2)0.030
FEV1 (% pred)67 (61–77)83 (32–89)0.222
FVC (% pred)67 (55–75)82 (47–96)0.171
TLC (% pred)74 (60–75)89 (68–95)0.093
Tlco (% pred)29 (23–62)51 (33–88)0.093
Anti-GM-CSF antibody in blood
    Immunoblotting (dilution)1000 (200–2000)1600 (1–4000)0.622
Anti-GM-CSF antibody in BAL fluid
    Immunoblotting (dilution)32 (2–64)4 (0.02–8)0.045
Chest radiographs
    Opacity score4 (2–6)4 (2–4)0.171
    Extent score6 (2–8)4 (2–6)0.284
    Severity score11 (5–18)8 (4–10)0.127
Chest HRCT scans
    Opacity score4 (2–5)3 (2–6)0.284
    Extent score7 (5–8)5 (2–6)0.030
    Severity score15 (6–22)8 (2–12)0.093
    Reticulation score6 (4–7)4 (3–6)0.045