Table 3

Relationship between anti-GM-CSF antibodies and severity indicators for iPAP

Variables	Anti-GM-CSF antibodies in blood		Anti-GM-CSF antibodies in BAL fluid
Variables	Correlation coefficient	p value	Correlation coefficient	p value
Anti-GM-CSF antibodies, anti-granulocyte-macrophage colony stimulating factor antibodies; BAL, bronchoalveolar lavage; LDH, lactate dehydrogenase; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; HRCT, high resolution computed tomography.
*Pao₂ and AaPo₂ were measured in the sitting position at room air.
AaPo₂ = Pao₂ – Pao₂; Pao₂ = (barometric pressure − 47) × Fio₂ − Paco₂/0.8.
Serum LDH (IU/l)	0.04	0.906	0.58	0.039
Pao₂ (kPa)*	−0.27	0.376	−0.69	0.009
AaPo₂ (kPa)*	0.38	0.201	0.77	0.002
FEV₁ (% pred)	−0.15	0.629	−0.11	0.738
FVC (% pred)	−0.21	0.498	−0.22	0.471
TLC (% pred)	−0.02	0.949	−0.44	0.133
Tlco (% pred)	−0.06	0.856	−0.62	0.024
Chest radiographs
Opacity score	0.32	0.283	0.65	0.016
Extent score	0.17	0.578	0.42	0.158
Severity score	0.12	0.678	0.50	0.080
Chest HRCT
Opacity score	0.08	0.805	0.35	0.242
Extent score	0.01	0.978	0.74	0.004
Severity score	0.07	0.812	0.48	0.100
Reticulation score	−0.04	0.898	0.58	0.038