Table 3

 Relationship between anti-GM-CSF antibodies and severity indicators for iPAP

VariablesAnti-GM-CSF antibodies in bloodAnti-GM-CSF antibodies in BAL fluid
Correlation coefficientp valueCorrelation coefficientp value
Anti-GM-CSF antibodies, anti-granulocyte-macrophage colony stimulating factor antibodies; BAL, bronchoalveolar lavage; LDH, lactate dehydrogenase; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; TLC, total lung capacity; Tlco, carbon monoxide transfer factor; HRCT, high resolution computed tomography.
*Pao2 and AaPo2 were measured in the sitting position at room air.
AaPo2  =  Pao2 – Pao2; Pao2  =  (barometric pressure − 47) × Fio2 − Paco2/0.8.
Serum LDH (IU/l)0.040.9060.580.039
Pao2 (kPa)*−0.270.376−0.690.009
AaPo2 (kPa)*0.380.2010.770.002
FEV1 (% pred)−0.150.629−0.110.738
FVC (% pred)−0.210.498−0.220.471
TLC (% pred)−0.020.949−0.440.133
Tlco (% pred)−0.060.856−0.620.024
Chest radiographs
    Opacity score0.320.2830.650.016
    Extent score0.170.5780.420.158
    Severity score0.120.6780.500.080
Chest HRCT
    Opacity score0.080.8050.350.242
    Extent score0.010.9780.740.004
    Severity score0.070.8120.480.100
    Reticulation score−0.040.8980.580.038