Perinatal characteristics of betamethasone and placebo exposed participants with adequate spirometric data at age 30
| Betamethasone(n = 181) | Placebo(n = 202) | p value | |
|---|---|---|---|
| Data are n (%), median (IQR), or mean (SD). | |||
| RDS, respiratory distress syndrome. | |||
| Maternal characteristics | |||
| Multiple pregnancy | 34 (19) | 22 (11) | 0.03 |
| Unplanned premature labour | 149 (82) | 162 (80) | 0.60 |
| Instrumental delivery | 103 (57) | 104 (51) | 0.29 |
| Complicated by hypertension | 19 (11) | 14 (7) | 0.21 |
| Gestational diabetes | 3 (2) | 2 (1) | 0.67 |
| Haemolytic disease | 7 (4) | 13 (6) | 0.26 |
| Median gestational age at entry (days) | 231 (217–243) | 234 (217–243) | 0.50 |
| Median entry/delivery interval (days) | 3.9 (1.6–35) | 4.2 (1.9–32) | 0.98 |
| Trial 1 | 117 (65) | 126 (62) | 0.65 |
| Smoking during pregnancy | 51 (28) | 53 (26) | 0.67 |
| Smoking during childhood | 98 (54) | 106 (52) | 0.74 |
| History of asthma | 34 (19) | 34 (17) | 0.62 |
| Paternal characteristics | |||
| Smoking during childhood | 92 (51) | 106 (52) | 0.75 |
| History of asthma | 25 (14) | 18 (9) | 0.13 |
| Neonatal characteristics | |||
| Male | 96 (53) | 91 (45) | 0.12 |
| Median gestational age delivery (days) | 245 (231–264) | 246 (235–266) | 0.41 |
| Term delivery | 52 (29) | 69 (34) | 0.25 |
| Mean birth weight (g) | 2318 (769) | 2361 (694) | 0.57 |
| Mean birth weight z score | −0.40 (0.90) | 0.39 (0.96) | 0.90 |
| Birth weight <10th centile | 29 (16) | 37 (18) | 0.55 |
| Fetal distress | 23 (13) | 31 (15) | 0.46 |
| 5 min Apgar score >7 | 137 (76) | 161 (80) | 0.35 |
| RDS | 11 (6) | 22 (11) | 0.09 |
| RDS, moderate or severe | 6 (3) | 16 (8) | 0.05 |