Distribution of ACE I/D and ET-1 −3A/−4A, G2288T and Lys198Asn polymorphisms and their combinations in the HAPE-p and HAPE-r
| Genotypes/genotype combinations* | HAPE-p(n = 64) | HAPE-r(n = 53) | χ2 | p value | OR (95% CI) |
|---|---|---|---|---|---|
| HAPE-p, individuals with high altitude pulmonary oedema; HAPE-r, individuals resistant to high altitude pulmonary oedema. | |||||
| The genotypes and genotype combinations are presented as number (%). | |||||
| *Genotype combinations were grouped into wild-type genotype combinations and remaining combinations. | |||||
| †(CT)n-(CA)n repeats were segregated and recognised as shorter (13–30) and longer (31–45). | |||||
| ACE | |||||
| II | 18 (28) | 23 (43) | |||
| ID | 34 (53) | 21 (40) | |||
| DD | 12 (19) | 9 (17) | 5.10 | 0.07 | |
| ID+DD | 46 (72) | 30 (57) | 4.91 | 0.03 | 1.94 (1.08 to 3.50) |
| ET-1 | |||||
| Longer repeats† | 17 (27) | 19 (35) | |||
| Shorter repeats† | 47 (73) | 34 (65) | 1.15 | 0.28 | 1.46 (0.80 to 2.66) |
| −3A/−3A | 44 (69) | 35 (66) | |||
| −3A/−4A | 20 (31) | 18 (34) | 0.21 | 0.65 | 0.87 (0.48 to 1.58) |
| GG | 15 (23) | 23 (43) | |||
| GT | 37 (58) | 22 (42) | |||
| TT | 12 (19) | 8 (15) | 9.09 | 0.01 | |
| GT+TT | 49 (77) | 30 (57) | 9.05 | 0.002 | 2.53 (1.37 to 4.65) |
| Lys198Lys | 22 (34) | 17 (31) | |||
| Lys198Asn | 32 (50) | 27 (52) | |||
| Asn198Asn | |||||
| Lys198Asn+ | 10 (16) | 9 (17) | 0.20 | 0.90 | |
| Asn198Asn | 42 (66) | 36 (69) | 0.65 | 0. 76 | 0.87 (0.48 to 1.58) |
| ACE+ET-1 | |||||
| II/Longer repeats | 1 (1) | 4 (8) | 0.12 (0.01 to 0.95) | ||
| Remaining combinations | 63 (99) | 49 (92) | 5.70 | 0.02 | |
| II/−3A/−3A | 13 (21) | 15 (28) | 0.68 (0.36 to 1.31) | ||
| Remaining combinations | 51 (79) | 38 (72) | 1.32 | 0.25 | |
| II/GG | 5 (7) | 12 (23) | 0.25 (0.10 to 0.62) | ||
| Remaining combinations | 59 (93) | 41 (77) | 10.04 | 0.002 | |
| II/Lys198Lys | 9 (14) | 8 (16) | 0.85 (0.39 to 1.86) | ||
| Remaining combinations | 55 (86) | 45 (84) | 0.15 | 0.69 | |