Adjusted regression coefficients (with 95% confidence intervals) for association between inflammatory markers and FEV1 % predicted in participants with and without obstructive lung disease (OLD)
| Variable | β with 95% confidence intervals* | p value† | |
|---|---|---|---|
| With OLD | Without OLD | ||
| IL-6, interleukin 6; TNF, tumour necrosis factor; CRP, C-reactive protein. | |||
| *Regression coefficients (β) denote the estimated difference in FEV1 % predicted associated with an increase of one log unit in individual inflammatory markers. β adjusted for age, race, sex, site, smoking status (current smokers, ever smoked versus never smoked), pack years of smoking, body mass index (>30 and <20 kg/m2), history of congestive heart failure, diabetes, and oral steroid use. | |||
| †p value for interaction between obstructive lung disease and the association between FEV1 and inflammatory marker. | |||
| IL-6 | −5.3 (−9.1 to −1.5) | −3.1 (−4.3 to −1.9) | 0.09 |
| TNF | 3.6 (−1.8 to 9) | −1.9 (−3.7 to 0.1) | 0.03 |
| CRP | −2.2 (−4.8 to 0.4) | −2 (−3 to −1) | 0.6 |